Intermolecular interactions involving aromatic rings are key processes in both chemical and
biological recognition. Their understanding is essential for rational drug design and lead …

The influence of a xenobiotic compound on an organism is usually summarized by the
expression biological activity. If a controlled, therapeutically relevant, and regulatory action …

Monoclonal antibodies play an increasingly important role for the development of new drugs
across multiple therapy areas. The term 'developability'encompasses the feasibility of …

Influenza virus remains a serious health threat, owing to its ability to evade immune
surveillance through rapid genetic drift and reassortment. Here we used a human non …

With increasing structural information on proteins, the opportunity to understand physical
forces governing protein folding is also expanding. One of the significant non‐covalent …

Abstract Zwischenmolekulare Wechselwirkungen unter Beteiligung aromatischer Ringe sind
Schlüsselvorgänge sowohl in chemischen als auch in biologischen Erkennungsprozessen …

Orthologs of the pentameric receptor channels that mediate fast synaptic transmission in the
central and peripheral nervous systems have been found in several bacterial species and in …

Phytopathogens deliver effector proteins inside host plant cells to promote infection. These
proteins can also be sensed by the plant immune system, leading to restriction of pathogen …

Although hydrophobic interaction is the main contributing factor to the stability of the protein
fold, the specificity of the folding process depends on many directional interactions. An …

The constrained backbone torsion angle of a proline (Pro) residue has usually been invoked
to explain its three-dimensional context in proteins. Here we show that specific interactions …