Inorganic polyphosphate: essential for growth and survival

NN Rao, MR Gómez-García… - Annual review of …, 2009 - annualreviews.org
Inorganic polyphosphate (Poly P) is a polymer of tens to hundreds of phosphate residues
linked by “high-energy” phosphoanhydride bonds as in ATP. Found in abundance in all cells …

Polyphosphate: an ancient molecule that links platelets, coagulation, and inflammation

JH Morrissey, SH Choi, SA Smith - Blood, The Journal of the …, 2012 - ashpublications.org
Inorganic polyphosphate is widespread in biology and exhibits striking prohemostatic,
prothrombotic, and proinflammatory effects in vivo. Long-chain polyphosphate (of the size …

Pyrophosphate inhibits mineralization of osteoblast cultures by binding to mineral, up-regulating osteopontin, and inhibiting alkaline phosphatase activity

WN Addison, F Azari, ES Sørensen… - Journal of Biological …, 2007 - ASBMB
Inorganic pyrophosphate (PP i) produced by cells inhibits mineralization by binding to
crystals. Its ubiquitous presence is thought to prevent" soft" tissues from mineralizing …

Polyphosphate exerts differential effects on blood clotting, depending on polymer size

SA Smith, SH Choi, R Davis-Harrison… - Blood, The Journal …, 2010 - ashpublications.org
Polyphosphate, a linear polymer of inorganic phosphate, is secreted by activated platelets
and accumulates in many infectious microorganisms. We recently showed that …

Polyphosphate enhances fibrin clot structure

SA Smith, JH Morrissey - Blood, The Journal of the American …, 2008 - ashpublications.org
Polyphosphate, a linear polymer of inorganic phosphate, is present in platelet dense
granules and is secreted on platelet activation. We recently reported that polyphosphate is a …

The long and short of it–polyphosphate, PPK and bacterial survival

MRW Brown, A Kornberg - Trends in biochemical sciences, 2008 - cell.com
Inorganic polyphosphate (poly P) is present in all species tested to date, from each of the
three kingdoms of life. Studied mainly in prokaryotes, poly P and its associated enzymes are …

Role of β-hydroxybutyrate, its polymer poly-β-hydroxybutyrate and inorganic polyphosphate in mammalian health and disease

EN Dedkova, LA Blatter - Frontiers in physiology, 2014 - frontiersin.org
We provide a comprehensive review of the role of β-hydroxybutyrate (β-OHB), its linear
polymer poly-β-hydroxybutyrate (PHB), and inorganic polyphosphate (polyP) in mammalian …

Inorganic polyphosphate in industry, agriculture and medicine: Modern state and outlook

TV Kulakovskaya, VM Vagabov, IS Kulaev - Process Biochemistry, 2012 - Elsevier
Inorganic polyphosphates (PolyP) are linear polymers containing a few to several hundred
orthophosphate residues linked by energy-rich phosphoanhydride bonds. PolyPs are widely …

Proliferation and differentiation of mesenchymal stem cells on scaffolds containing chitosan, calcium polyphosphate and pigeonite for bone tissue engineering

S Dhivya, A Keshav Narayan, R Logith Kumar… - Cell …, 2018 - Wiley Online Library
Objectives Treatment of critical‐sized bone defects with cells and biomaterials offers an
efficient alternative to traditional bone grafts. Chitosan (CS) is a natural biopolymer that acts …

Critical and diverse roles of phosphates in human bone formation

EAB Hughes, TE Robinson, DB Bassett… - Journal of Materials …, 2019 - pubs.rsc.org
Humans utilise biomineralisation in the formation of bone and teeth. Human
biomineralisation processes are defined by the transformation of an amorphous phosphate …