The function of neural circuits and networks can be controlled, in part, by modulating the
synchrony of their components' activities. Network hypersynchrony and altered oscillatory …

Fast-spiking parvalbumin (PV) interneurons are inhibitory interneurons with unique
morphological and functional properties that allow them to precisely control local circuitry …

Background Microglial activation-mediated neuroinflammation is one of the essential
pathogenic mechanisms of sepsis-associated encephalopathy (SAE). Mounting evidence …

The extracellular matrix (ECM) is known to regulate important processes in neuronal cell
development, activity and growth. It is associated with the structural stabilization of neuronal …

G protein-gated inwardly rectifying potassium channels (Kir3/GirK) are important for
maintaining resting membrane potential, cell excitability and inhibitory neurotransmission …

Alzheimer's disease (AD) is a devastating disorder of increasing prevalence in modern
society. Mild cognitive impairment (MCI) is considered a transitional stage between normal …

Deep brain stimulation (DBS) is a neurosurgical technique that regulates neuron activity by
using internal pulse generators to electrodes in specific target areas of the brain. As a blind …

Synapses are specialized structures that mediate rapid and efficient signal transmission
between neurons and are surrounded by glial cells. Astrocytes develop an intimate …

Alzheimer's disease (AD) is characterized by the classical hallmarks of Aβ-deposition and
tau-pathology that are thought to ultimately lead to synapse and neuron loss. Although long …

Background Abnormal accumulation of amyloid β 1–42 oligomers (AβO 1–42), a hallmark of
Alzheimer's disease, impairs hippocampal theta-nested gamma oscillations and long-term …