Application of biomarker-derived fluorescent probes for the detection of Alzheimer's disease

H Ding, Z Li, K Luo, Q Gong, X Tian - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the
accumulation of beta-amyloid (Aβ) protein and neurofibrillary tangles in the brain, resulting …

Depression in Alzheimer's disease: epidemiology, mechanisms, and treatment

YY Huang, YH Gan, L Yang, W Cheng, JT Yu - Biological Psychiatry, 2024 - Elsevier
Depression and Alzheimer's disease (AD) are substantial public health concerns. In the past
decades, a link between the 2 disease entities has received extensive acknowledgment, yet …

Microbiota from Alzheimer's patients induce deficits in cognition and hippocampal neurogenesis

S Grabrucker, M Marizzoni, E Silajdžić, N Lopizzo… - Brain, 2023 - academic.oup.com
Alzheimer's disease is a complex neurodegenerative disorder leading to a decline in
cognitive function and mental health. Recent research has positioned the gut microbiota as …

Nerve growth factor receptor (Ngfr) induces neurogenic plasticity by suppressing reactive astroglial Lcn2/Slc22a17 signaling in Alzheimer's disease

T Siddiqui, MI Cosacak, S Popova, P Bhattarai… - NPJ Regenerative …, 2023 - nature.com
Neurogenesis, crucial for brain resilience, is reduced in Alzheimer's disease (AD) that
induces astroglial reactivity at the expense of the pro-neurogenic potential, and restoring …

Pleiotrophin ameliorates age-induced adult hippocampal neurogenesis decline and cognitive dysfunction

H Li, L Xu, W Jiang, X Qiu, H Xu, F Zhu, Y Hu, S Liang… - Cell Reports, 2023 - cell.com
Cognitive impairment has been associated with an age-related decline in adult hippocampal
neurogenesis (AHN). The molecular basis of declining neurogenesis in the aging …

Cerebral organoids derived from patients with Alzheimer's disease with PSEN1/2 mutations have defective tissue patterning and altered development

T Vanova, J Sedmik, J Raska, KA Cerna, P Taus… - Cell Reports, 2023 - cell.com
During the past two decades, induced pluripotent stem cells (iPSCs) have been widely used
to study human neural development and disease. Especially in the field of Alzheimer's …

Dapagliflozin ameliorates cognitive impairment in Aluminum-chloride-induced Alzheimer's disease via modulation of AMPK/mTOR, oxidative stress and glucose …

WA Samman, SM Selim, HM El Fayoumi, NM El-Sayed… - Pharmaceuticals, 2023 - mdpi.com
Alzheimer's disease (AD) is a progressive neurological illness characterized by memory loss
and cognitive deterioration. Dapagliflozin was suggested to attenuate the memory …

WNT-β catenin signaling as a potential therapeutic target for neurodegenerative diseases: current status and future perspective

K Ramakrishna, LV Nalla, D Naresh, K Venkateswarlu… - Diseases, 2023 - mdpi.com
Wnt/β-catenin (WβC) signaling pathway is an important signaling pathway for the
maintenance of cellular homeostasis from the embryonic developmental stages to …

Radial stem astrocytes (aka neural stem cells): identity, development, physio‐pathology, and therapeutic potential

CY Yeh, KY Wu, GJ Huang, A Verkhratsky - Acta Physiologica, 2023 - Wiley Online Library
Adult neurogenesis is a striking example of neuroplasticity, which enables adaptive network
remodelling in response to all forms of environmental stimulation in physiological and …

Traumatic brain injury promotes neurogenesis at the cost of astrogliogenesis in the adult hippocampus of male mice

P Bielefeld, A Martirosyan, S Martín-Suárez… - Nature …, 2024 - nature.com
Traumatic brain injury (TBI) can result in long-lasting changes in hippocampal function. The
changes induced by TBI on the hippocampus contribute to cognitive deficits. The adult …