Tumor necrosis factor (TNF) is a pleiotropic cytokine powerfully influencing diverse
processes of the central nervous system (CNS) under both physiological and pathological …

Neuropsychiatric disorders and type 2 diabetes (T2D) are major public health concerns
proposed to be intimately connected. T2D is associated with increased risk of dementia …

Inflammation is a potential factor in the pathophysiology of depression. A traditional Chinese
herbal medicine, arctiin, and its aglycone, arctigenin, are the major bioactive components in …

Dopamine is a well-known neurotransmitter due to its involvement in Parkinson's disease
(PD). Dopamine is not only involved in PD but also controls multiple mental and physical …

Previous studies have shown that exposure to circadian disruption produces negative
effects on overall health and behavior. More recent studies illustrate that strain differences in …

This study was to study the impact of aerobic exercises on the chronic unpredictable mild
stress (CUMS) in mice, and to discuss the possible mechanism from the skeletal muscle …

The known effects of aging on the brain and behavior include impaired cognition, increases
in anxiety and depressive-like behaviors, and reduced locomotor activity. Environmental …

(1) Background: Depression is one of the overwhelming public health problems. Alleviating
hippocampus injury may prevent depression development. Herein, we established the …

Background Altered TNF levels are associated with cognitive impairment in depression,
schizophrenia, bipolar disorder, and Alzheimer's disease (AD). Exercise improves cognition …

Background We recently reported that tumor necrosis factor (TNF) signaling via the TNFR1
and TNFR2 receptors mediates the effects of long-term exercise on locomotion, cognition …