[HTML][HTML] Neuroimmune signaling in alcohol use disorder
Alcohol use disorder (AUD) is a widespread disease with limited treatment options.
Targeting the neuroimmune system is a new avenue for developing or repurposing effective …
Targeting the neuroimmune system is a new avenue for developing or repurposing effective …
Neuroimmune mechanisms as novel treatment targets for substance use disorders and associated comorbidities
MD Namba, JM Leyrer-Jackson, EK Nagy… - Frontiers in …, 2021 - frontiersin.org
Recent studies examining the neurobiology of substance abuse have revealed a significant
role of neuroimmune signaling as a mechanism through which drugs of abuse induce …
role of neuroimmune signaling as a mechanism through which drugs of abuse induce …
Immune treatments for alcohol use disorder: A translational framework
While the immune system is essential for survival, an excessive or prolonged inflammatory
response, such as that resulting from sustained heavy alcohol use, can damage the host …
response, such as that resulting from sustained heavy alcohol use, can damage the host …
Medications for alcohol use disorders: An overview
Patients who suffer from alcohol use disorders (AUDs) usually go through various socio-
behavioral and pathophysiological changes that take place in the brain and other organs …
behavioral and pathophysiological changes that take place in the brain and other organs …
Rat animal models for screening medications to treat alcohol use disorders
The purpose of this review is to present animal research models that can be used to screen
and/or repurpose medications for the treatment of alcohol abuse and dependence. The …
and/or repurpose medications for the treatment of alcohol abuse and dependence. The …
Fenofibrate decreases ethanol-induced neuroinflammation and oxidative stress and reduces alcohol relapse in rats by a PPAR-α-dependent mechanism
C Ibáñez, T Acuña, ME Quintanilla, D Pérez-Reytor… - Antioxidants, 2023 - mdpi.com
High ethanol consumption triggers neuroinflammation, implicated in sustaining chronic
alcohol use. This inflammation boosts glutamate, prompting dopamine release in reward …
alcohol use. This inflammation boosts glutamate, prompting dopamine release in reward …
Therapeutic potential of peroxisome proliferator-activated receptor (PPAR) agonists in substance use disorders: a synthesis of preclinical and human evidence
J Matheson, B Le Foll - Cells, 2020 - mdpi.com
Targeting peroxisome proliferator-activated receptors (PPARs) has received increasing
interest as a potential strategy to treat substance use disorders due to the localization of …
interest as a potential strategy to treat substance use disorders due to the localization of …
A review on the reciprocal interactions between neuroinflammatory processes and substance use and misuse, with a focus on alcohol misuse
Background: The last decade has witnessed a surge of findings implicating
neuroinflammatory processes as pivotal players in substance use disorders. The …
neuroinflammatory processes as pivotal players in substance use disorders. The …
Its complicated: The relationship between alcohol and microglia in the search for novel pharmacotherapeutic targets for alcohol use disorders
Alcohol use disorder (AUD) is a chronic relapsing disorder with wide-ranging health
consequences. Alcohol targets the central nervous system producing neurodegeneration …
consequences. Alcohol targets the central nervous system producing neurodegeneration …
The impact of single and combined PPAR-α and PPAR-γ activation on the neurological outcomes following cerebral ischemia reperfusion
Aim The neuronal damage and accompanied functional deficits induced by cerebral
ischemia are among the most common causes of disabilities in adults. Activation of subtypes …
ischemia are among the most common causes of disabilities in adults. Activation of subtypes …