Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary brain
tumour in humans and has a very poor prognosis. The existing treatments have had limited …

Protein tyrosine kinase (PTK) is one of the major signaling enzymes in the process of cell
signal transduction, which catalyzes the transfer of ATP-γ-phosphate to the tyrosine residues …

We report a comprehensive proteogenomics analysis, including whole-genome sequencing,
RNA sequencing, and proteomics and phosphoproteomics profiling, of 218 tumors across 7 …

Brain tumors, although rare, contribute to distinct mortality and morbidity at all ages.
Although there are few therapeutic options for brain tumors, enhanced biological …

Summary Histone H3. 3 glycine 34 to arginine/valine (G34R/V) mutations drive deadly
gliomas and show exquisite regional and temporal specificity, suggesting a developmental …

In theory, in vitro and in vivo models for human gliomas have great potential to not only
enhance our understanding of glioma biology, but also to facilitate the development of novel …

Glioblastoma multiforme (GBM) is among the most incurable cancers. GBMs survival rate
has not markedly improved, despite new radical surgery protocols, the introduction of new …

Pediatric central nervous system tumors are the most common solid malignancies in
childhood, and aggressive therapy often leads to long-term sequelae in survivors, making …

Abstract Background Receptor tyrosine kinases (RTKs) are signaling enzymes responsible
for the transfer of Adenosine triphosphate (ATP) γ-phosphate to the tyrosine residues …

Background Glioblastoma multiforme (GBM), a lethal brain tumor, remains the most daunting
challenge in cancer therapy. Overexpression and constitutive activation of PDGFs and …