Glioblastoma multiforme (GBM): An overview of current therapies and mechanisms of resistance
Glioblastoma multiforme (GBM) is a WHO grade IV glioma and the most common malignant,
primary brain tumor with a 5-year survival of 7.2%. Its highly infiltrative nature, genetic …
primary brain tumor with a 5-year survival of 7.2%. Its highly infiltrative nature, genetic …
[HTML][HTML] Evidence-based recommendations on categories for extent of resection in diffuse glioma
P Karschnia, MA Vogelbaum, M van den Bent… - European Journal of …, 2021 - Elsevier
Surgical resection represents the standard of care in diffuse glioma, and more extensive
tumour resection appears to be associated with favourable outcome. Up to now, terminology …
tumour resection appears to be associated with favourable outcome. Up to now, terminology …
Association of maximal extent of resection of contrast-enhanced and non–contrast-enhanced tumor with survival within molecular subgroups of patients with newly …
Importance Per the World Health Organization 2016 integrative classification, newly
diagnosed glioblastomas are separated into isocitrate dehydrogenase gene 1 or 2 (IDH) …
diagnosed glioblastomas are separated into isocitrate dehydrogenase gene 1 or 2 (IDH) …
Prognostic validation of a new classification system for extent of resection in glioblastoma: A report of the RANO resect group
Background Terminology to describe extent of resection in glioblastoma is inconsistent
across clinical trials. A surgical classification system was previously proposed based upon …
across clinical trials. A surgical classification system was previously proposed based upon …
Human glioblastoma arises from subventricular zone cells with low-level driver mutations
Glioblastoma (GBM) is a devastating and incurable brain tumour, with a median overall
survival of fifteen months,. Identifying the cell of origin that harbours mutations that drive …
survival of fifteen months,. Identifying the cell of origin that harbours mutations that drive …
Association of the extent of resection with survival in glioblastoma: a systematic review and meta-analysis
Importance Glioblastoma multiforme (GBM) remains almost invariably fatal despite optimal
surgical and medical therapy. The association between the extent of tumor resection (EOR) …
surgical and medical therapy. The association between the extent of tumor resection (EOR) …
5-ALA and FDA approval for glioma surgery
CG Hadjipanayis, W Stummer - Journal of neuro-oncology, 2019 - Springer
Abstract The US Food and Drug Administration (FDA) approved 5-aminolevulinic acid (5-
ALA; Gleolan®; photonamic GmbH and Co. KG) for use as an intraoperative optical imaging …
ALA; Gleolan®; photonamic GmbH and Co. KG) for use as an intraoperative optical imaging …
[HTML][HTML] DeepSeg: deep neural network framework for automatic brain tumor segmentation using magnetic resonance FLAIR images
Purpose Gliomas are the most common and aggressive type of brain tumors due to their
infiltrative nature and rapid progression. The process of distinguishing tumor boundaries …
infiltrative nature and rapid progression. The process of distinguishing tumor boundaries …
Current standards of care in glioblastoma therapy
C Fernandes, A Costa, L Osório, RC Lago… - Exon …, 2017 - exonpublications.com
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults.
Regardless of ideal multidisciplinary treatment, including maximal surgical resection …
Regardless of ideal multidisciplinary treatment, including maximal surgical resection …
Surgical oncology for gliomas: the state of the art
N Sanai, MS Berger - Nature Reviews Clinical Oncology, 2018 - nature.com
Surgical resection remains the mainstay of treatment for patients with glioma of any grade.
Maximal resection of the tumour is central to achieving long-term disease control; however …
Maximal resection of the tumour is central to achieving long-term disease control; however …