Chemistry of MRI contrast agents: current challenges and new frontiers

J Wahsner, EM Gale, A Rodríguez-Rodríguez… - Chemical …, 2018 - ACS Publications
Tens of millions of contrast-enhanced magnetic resonance imaging (MRI) exams are
performed annually around the world. The contrast agents, which improve diagnostic …

Chemical design and synthesis of functionalized probes for imaging and treating tumor hypoxia

J Liu, W Bu, J Shi - Chemical reviews, 2017 - ACS Publications
Hypoxia development in tumor is closely associated with its increased aggressiveness and
strong resistance to therapy, leading to the poor prognosis in several cancer types …

New anti-cancer explorations based on metal ions

H Hu, Q Xu, Z Mo, X Hu, Q He, Z Zhang… - Journal of …, 2022 - Springer
Due to the urgent demand for more anti-cancer methods, the new applications of metal ions
in cancer have attracted increasing attention. Especially the three kinds of the new mode of …

Chemical exchange saturation transfer (CEST): what is in a name and what isn't?

PCM Van Zijl, NN Yadav - Magnetic resonance in medicine, 2011 - Wiley Online Library
Chemical exchange saturation transfer (CEST) imaging is a relatively new magnetic
resonance imaging contrast approach in which exogenous or endogenous compounds …

Alternatives to gadolinium-based metal chelates for magnetic resonance imaging

S Viswanathan, Z Kovacs, KN Green… - Chemical …, 2010 - ACS Publications
Magnetic resonance imaging (MRI) has been immensely valuable in diagnostic clinical
imaging over the last few decades owing to its exceptional spatial and anatomical …

Biomedical applications of macrocyclic ligand complexes

RE Mewis, SJ Archibald - Coordination Chemistry Reviews, 2010 - Elsevier
Macrocyclic chelators can form highly stable complexes with transition metals and
lanthanides. In this review, the recent advances towards biomedical applications of …

Gadolinium (III) complexes as MRI contrast agents: ligand design and properties of the complexes

P Hermann, J Kotek, V Kubíček, I Lukeš - Dalton Transactions, 2008 - pubs.rsc.org
Magnetic resonance imaging is a commonly used diagnostic method in medicinal practice
as well as in biological and preclinical research. Contrast agents (CAs), which are often …

Chemical exchange saturation transfer contrast agents for magnetic resonance imaging

AD Sherry, M Woods - Annu. Rev. Biomed. Eng., 2008 - annualreviews.org
Magnetic resonance imaging (MRI) contrast agents have become an important tool in
clinical medicine. The most common agents are Gd3+-based complexes that shorten bulk …

A concentration‐independent method to measure exchange rates in PARACEST agents

WT Dixon, J Ren, AJM Lubag… - Magnetic resonance …, 2010 - Wiley Online Library
The efficiency of chemical exchange dependent saturation transfer (CEST) agents is largely
determined by their water or proton exchange kinetics, yet methods to measure such …

Layer-by-layer capsules for magnetic resonance imaging and drug delivery

H Ai - Advanced drug delivery reviews, 2011 - Elsevier
Layer-by-layer (LbL) self-assembled polyelectrolyte capsules have demonstrated their
unique advantages and capability in drug delivery applications. These ordered micro/nano …