[HTML][HTML] Concomitant inhibition of PPARγ and mTORC1 induces the differentiation of human monocytes into highly immunogenic dendritic cells

FE Diaz, I Mazzitelli, L Bleichmar, C Melucci… - Cell Reports, 2023 - cell.com
Monocytes can differentiate into macrophages (Mo-Macs) or dendritic cells (Mo-DCs). The
cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) induces the …

[HTML][HTML] SECTM1 promotes the development of glioblastoma and mesenchymal transition by regulating the TGFβ1/Smad signaling pathway

Z Yao, F Zhang, C Qi, C Wang, M Mao… - … Journal of Biological …, 2024 - ncbi.nlm.nih.gov
Objective: Secreted and transmembrane protein 1 (SECTM1) is a gene encoding a
transmembrane protein. The role of SECTM1 in glioblastoma (GBM) is unclear. Here, we …

[HTML][HTML] Plasma host protein biomarkers correlating with increasing Mycobacterium tuberculosis infection activity prior to tuberculosis diagnosis in people living with …

SN Singer, OC Ndumnego, RS Kim, T Ndung'u… - …, 2022 - thelancet.com
Summary Background Biomarkers correlating with Mycobacterium tuberculosis infection
activity/burden in asymptomatic individuals are urgently needed to identify and treat those at …

Identifying spatial co-occurrence in healthy and inflamed tissues (ISCHIA)

A Lafzi, C Borrelli, S Baghai Sain, K Bach… - Molecular Systems …, 2024 - embopress.org
Sequencing-based spatial transcriptomics (ST) methods allow unbiased capturing of RNA
molecules at barcoded spots, charting the distribution and localization of cell types and …

SECTM1 is upregulated in immuno-hot tumors and predicts immunotherapeutic efficacy in multiple cancers

J Mei, Z Fu, Y Cai, C Song, J Zhou, Y Zhu, W Mao, J Xu… - Iscience, 2023 - cell.com
Immune checkpoint inhibitors (ICIs) have transformed the management of advanced
cancers. However, many patients could not benefit from ICIs therapy, and thus several …

[HTML][HTML] Macrophage-enriched Sectm1a promotes efficient efferocytosis to attenuate ischemia/reperfusion-induced cardiac injury

X Wang, W Du, Y Li, HH Yang, Y Zhang, R Akbar… - JCI insight, 2024 - ncbi.nlm.nih.gov
Efficient clearance and degradation of apoptotic cardiomyocytes by macrophages
(collectively termed efferocytosis) is critical for inflammation resolution and restoration of …

The proteomic landscape of in vitro cultured endothelial cells across vascular beds

SA Groten, ER Smit, M van den Biggelaar… - Communications …, 2024 - nature.com
Blood vessel endothelial cells (EC) display heterogeneity across vascular beds, which is
anticipated to drive site-specific vascular pathology. This heterogeneity is assessed using …

K12/SECTM1, an interferon-γ regulated molecule, synergizes with CD28 to costimulate human T cell proliferation

T Wang, C Huang, A Lopez-Coral… - Journal of leukocyte …, 2012 - academic.oup.com
ABSTRACT CD7 is a cell-surface molecule, expressed on T lymphocytes and NK cells,
which functions as a costimulatory receptor for T cell proliferation. SECTM1 has been …

Sectm1a deficiency aggravates inflammation-triggered cardiac dysfunction through disruption of LXRα signalling in macrophages

Y Li, S Deng, X Wang, W Huang, J Chen… - Cardiovascular …, 2021 - academic.oup.com
Aims Cardiac dysfunction is a prevalent comorbidity of disrupted inflammatory homeostasis
observed in conditions such as sepsis (acute) or obesity (chronic). Secreted and …

Sex-dependent gene expression after ochratoxin A insult in F344 rat kidney

A Vettorazzi, L Pastor, E Guruceaga… - Food and Chemical …, 2019 - Elsevier
Ochratoxin A (OTA) is a potent rodent nephrocarcinogen; being males more sensitive than
females. The objective was to study the response between sexes at gene expression level …