As the principal tissue for insulin-stimulated glucose disposal, skeletal muscle is a primary
driver of whole-body glycemic control. Skeletal muscle also uniquely responds to muscle …

Both the consumption of a diet rich in fatty acids and exercise training result in similar
adaptations in several skeletal muscle proteins. These adaptations are involved in fatty acid …

Excessive energy intake and reduced energy expenditure drive the development of insulin
resistance and metabolic diseases such as obesity and type 2 diabetes mellitus. Metabolic …

Abstract The (pro) renin receptor ((P) RR) was first identified as a single-transmembrane
receptor in human kidneys and initially attracted attention owing to its potential role as a …

Highlights•Traditional calorie restriction robustly improves markers of aging in
humans.•Novel dietary strategies may be substitutes for calorie restriction.•Intermittent …

Prolonged intervention studies investigating molecular metabolism are necessary for a
deeper understanding of dietary effects on health. Here we provide mechanistic information …

Hyperinsulinemia is the hallmark of insulin resistance in obesity, and the relative importance
of insulin clearance, insulin resistance, and insulin hypersecretion has been widely debated …

It is well recognized that whole-body fatty acid (FA) oxidation remains increased for several
hours following aerobic endurance exercise, even despite carbohydrate intake. However …

Context Skeletal muscle molecular mechanisms underlying insulin resistance in women with
polycystic ovary syndrome (PCOS) are poorly understood. Objective To provide insight into …

The metabolic syndrome is a cluster of overlapping conditions resulting in an increased
incidence of type 2 diabetes, cardiovascular disease, and cancer. In the last few decades …