Antiarrhythmic strategies have changed dramatically during the last decade. The Cardiac
Arrhythmia Suppres-Ž. sion Trial CAST reported the harmful effects of flecainide, encainide …

Amiodarone is the most promising drug in the treatment of life-threatening ventricular
tachyarrhythmias in patients with significant structural heart disease. The pharmacologic …

Background—In a multicenter, double-blind, placebo-controlled study, the long-term effects
of amiodarone on morbidity and mortality in patients with congestive heart failure (CHF) and …

A 24 h intravenous dosing regimen of amiodarone was designed to reach a peak plasma
concentration at 1 h and to maintain the concentration above a certain level during the …

Although synthesized as a coronary dilator for use as an antianginal agent over 20 years
ago, amiodarone hydrochloride has recently drawn much attention as a potent …

In a randomized, double-blind, controlled study of 98 patients with atrial fibrillation
(AF)(present for≥ 30 minutes,≤ 72 hours, and a ventricular response of≥ 100 beats/min) …

Background—To overcome the side effects of amiodarone (AM), its noniodinated analogue,
dronedarone (SR), was synthesized. In this study, its electrophysiological effects were …

Aims This study compared the efficacy and safety of intravenous dofetilide with amiodarone
and placebo in converting atrial fibrillation or flutter to sinus rhythm. Methods and Results …

Amiodarone, a complex compound with variegated electropharmacologic and
pharmacokinetic properties and an equally complex side-effect profile, continues to have a …

Aims Grapefruit juice increases blood concentrations of many drugs metabolized by CYP3A.
Amiodarone is metabolized by CYP3A to N‐desethylamiodarone (N‐DEA). The aim of this …