Understanding early-life adaptive immunity to guide interventions for pediatric health

EC Semmes, JL Chen, R Goswami, TD Burt… - Frontiers in …, 2021 - frontiersin.org
Infants are capable of mounting adaptive immune responses, but their ability to develop long-
lasting immunity is limited. Understanding the particularities of the neonatal adaptive …

Neonatal T cells: a reinterpretation

BD Rudd - Annual review of immunology, 2020 - annualreviews.org
Neonatal CD4+ and CD8+ T cells have historically been characterized as immature or
defective. However, recent studies prompt a reinterpretation of the functions of neonatal T …

Prospective epigenome and transcriptome analyses of cord and peripheral blood from preterm infants at risk of bronchopulmonary dysplasia

HY Cho, X Wang, MR Campbell, V Panduri… - Scientific Reports, 2023 - nature.com
Bronchopulmonary dysplasia (BPD) is a prevalent chronic lung disease of prematurity with
limited treatment options. To uncover biomarkers of BPD risk, this study investigated …

[HTML][HTML] The impact of maternal asthma on the fetal lung: Outcomes, mechanisms and interventions

JL Robinson, KL Gatford, VL Clifton, JL Morrison… - Paediatric Respiratory …, 2023 - Elsevier
Maternal asthma affects up to 17% of pregnancies and is associated with adverse infant,
childhood, and adult respiratory outcomes, including increased risks of neonatal respiratory …

Perinatal inflammation influences but does not arrest rapid immune development in preterm babies

S Kamdar, R Hutchinson, A Laing, F Stacey… - Nature …, 2020 - nature.com
Infection and infection-related complications are important causes of death and morbidity
following preterm birth. Despite this risk, there is limited understanding of the development of …

Premature skewing of T cell receptor clonality and delayed memory expansion in HIV-exposed infants

S Dzanibe, AJ Wilk, S Canny, T Ranganath… - Nature …, 2024 - nature.com
While preventing vertical HIV transmission has been very successful, HIV-exposed
uninfected infants (iHEU) experience an elevated risk to infections compared to HIV …

Influenza: Toward understanding the immune response in the young

S Sakleshpur, AL Steed - Frontiers in Pediatrics, 2022 - frontiersin.org
Annually influenza causes a global epidemic resulting in 290,000 to 650,000 deaths and
extracts a massive toll on healthcare and the economy. Infants and children are more …

Characterization of the γδ T‐cell compartment during infancy reveals clear differences between the early neonatal period and 2 years of age

M van der Heiden, S Björkander… - Immunology and cell …, 2020 - Wiley Online Library
Abstract γδ T cells are unconventional T cells that function on the border of innate and
adaptive immunity. They are suggested to play important roles in neonatal and infant …

CD8A is a promising biomarker associated with immunocytes infiltration in hyperoxia-induced bronchopulmonary dysplasia

Y Du, L Zuo, Y Xiong, X Wang, J Zou… - Journal of Inflammation …, 2023 - Taylor & Francis
Background Bronchopulmonary dysplasia (BPD) refers to a chronic lung disease which is
commonly observed in preterm infants. It can usually be caused by several pathological …

Lymphocyte-specific biomarkers associated with preterm birth and bronchopulmonary dysplasia

S Bhattacharya, JA Mereness, AM Baran… - Frontiers in …, 2021 - frontiersin.org
Many premature babies who are born with neonatal respiratory distress syndrome (RDS) go
on to develop Bronchopulmonary Dysplasia (BPD) and later Post-Prematurity Respiratory …