A comprehensive review on MAPK: a promising therapeutic target in cancer
The mitogen-activated protein kinase (MAPK) pathway is an important bridge in the switch
from extracellular signals to intracellular responses. Alterations of signaling cascades are …
from extracellular signals to intracellular responses. Alterations of signaling cascades are …
[HTML][HTML] Structural basis for the non-catalytic functions of protein kinases
Protein kinases are known primarily for their ability to phosphorylate protein substrates,
which constitutes an essential biological process. Recently, compelling evidence has …
which constitutes an essential biological process. Recently, compelling evidence has …
Small molecule inhibition of ERK dimerization prevents tumorigenesis by RAS-ERK pathway oncogenes
Nearly 50% of human malignancies exhibit unregulated RAS-ERK signaling; inhibiting it is a
valid strategy for antineoplastic intervention. Upon activation, ERK dimerize, which is …
valid strategy for antineoplastic intervention. Upon activation, ERK dimerize, which is …
Sulforaphane suppresses metastasis of triple-negative breast cancer cells by targeting the RAF/MEK/ERK pathway
Y Zhang, Q Lu, N Li, M Xu, T Miyamoto, J Liu - NPJ Breast Cancer, 2022 - nature.com
Breast cancer metastasis is the main cause of cancer death in women, so far, no effective
treatment has inhibited breast cancer metastasis. Sulforaphane (SFN), a natural compound …
treatment has inhibited breast cancer metastasis. Sulforaphane (SFN), a natural compound …
RAF kinase dimerization: implications for drug discovery and clinical outcomes
T Brummer, C McInnes - Oncogene, 2020 - nature.com
The RAF kinases activated by RAS GTPases regulate cell growth and division by signal
transduction through the ERK cascade and mutations leading to constitutive activity are key …
transduction through the ERK cascade and mutations leading to constitutive activity are key …
Actionability classification of variants of unknown significance correlates with functional effect
A Johnson, PKS Ng, M Kahle, J Castillo… - npj Precision …, 2023 - nature.com
Genomically-informed therapy requires consideration of the functional impact of genomic
alterations on protein expression and/or function. However, a substantial number of variants …
alterations on protein expression and/or function. However, a substantial number of variants …
Computational identification of novel stage-specific biomarkers in colorectal cancer progression
A Palaniappan, K Ramar, S Ramalingam - PloS one, 2016 - journals.plos.org
It is well-known that the conversion of normal colon epithelium to adenoma and then to
carcinoma stems from acquired molecular changes in the genome. The genetic basis of …
carcinoma stems from acquired molecular changes in the genome. The genetic basis of …
Analysis of RAS and drug induced homo-and heterodimerization of RAF and KSR1 proteins in living cells using split Nanoluc luciferase
L Rohrer, C Spohr, C Beha, R Griffin, S Braun… - Cell Communication and …, 2023 - Springer
The dimerization of RAF kinases represents a key event in their activation cycle and in
RAS/ERK pathway activation. Genetic, biochemical and structural approaches provided key …
RAS/ERK pathway activation. Genetic, biochemical and structural approaches provided key …
The complexities and versatility of the RAS-to-ERK signalling system in normal and cancer cells
The intricate dynamic control and plasticity of RAS to ERK mitogenic, survival and apoptotic
signalling has mystified researches for more than 30 years. Therapeutics targeting the …
signalling has mystified researches for more than 30 years. Therapeutics targeting the …
ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1
RAF protein kinases are effectors of the GTP-bound form of small guanosine triphosphatase
RAS and function by phosphorylating MEK. We showed here that the expression of ARAF …
RAS and function by phosphorylating MEK. We showed here that the expression of ARAF …