Obesity is now a worldwide epidemic ensuing an increase in comorbidities' prevalence,
such as insulin resistance, type 2 diabetes (T2D), metabolic dysfunction-associated fatty …

Hepatic stellate cells (HSCs) activation play a significant role in the progression of hepatic
fibrosis. During chronic liver diseases, hepatocytes are damaged severely and secrete …

Ferroptosis is a recently discovered form of programmed cell death, but its regulatory
mechanisms remain poorly understood. Here, we show that the RNA-binding protein …

Background & Aims Increased hepatocyte death contributes to the pathology of acute and
chronic liver diseases. However, the role of hepatocyte pyroptosis and extracellular …

The interplay between western diet and gut microbiota drives the development of non-
alcoholic fatty liver disease and its progression to non-alcoholic steatohepatitis. However …

Ferroptosis is a recently recognized form of regulated cell death that is characterized by lipid
peroxidation. However, the molecular mechanisms regulating ferroptosis are largely …

The intestinal extracellular matrix (ECM) represents a complex network of proteins that not
only forms a support structure for resident cells but also interacts closely with them by …

Background & Aims Although the tumor microenvironment plays an important role in tumor
growth, it is not fully understood what role hepatic stellate cells (HSCs) play in the …

Background Effective therapeutics to stop or reverse liver fibrosis have not emerged,
because these potential agents cannot specifically target activated hepatic stellate cells …

The incidence of non-alcoholic fatty liver disease (NAFLD) has increased significantly over
the past two decades. NAFLD ranges from simple steatosis (NAFL) to nonalcoholic …