Kidneys are central in the regulation of multiple physiological functions, such as removal of
metabolic wastes and toxins, maintenance of electrolyte and fluid balance, and control of pH …

The kidneys have a central role in the control of acid–base homeostasis owing to
bicarbonate reabsorption and production of ammonia and ammonium in the proximal tubule …

Local acidification is a common feature of many disease processes such as inflammation,
infarction, or solid tumor growth. Acidic pH is not merely a sequela of disease but contributes …

Increasing numbers of studies have shown that tumor cells prefer fermentative glycolysis
over oxidative phosphorylation to provide a vast amount of energy for fast proliferation even …

Inflammatory bowel disease (IBD) is a lifelong inflammatory immune mediated disorder,
encompassing Crohn's disease (CD) and ulcerative colitis (UC); however, the cause and …

Ovarian cancer G protein-coupled receptor 1 (OGR1)(Gpr68) and G protein-coupled
receptor 4 (GPR4)(Gpr4) are proton-activated G protein-coupled receptors that are …

The cerebrospinal fluid (CSF) fills the brain ventricles and the subarachnoid space
surrounding the brain and spinal cord. The fluid compartment of the brain ventricles …

Abstract Proton-sensing G Protein Coupled Receptors (GPCRs) sense changes in the
extracellular pH to effect cell signaling for cellular homeostasis. They tend to be …

G-protein-coupled receptors (GPRs), including pro-inflammatory ovarian cancer GPR1
(OGR1/GPR68) and anti-inflammatory T cell death-associated gene 8 (TDAG8/GPR65), are …

Abstract Changes in extracellular proton concentrations occur in a variety of tissues over a
range of timescales under physiological conditions and also accompany virtually all …