Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool?

M Kou, L Huang, J Yang, Z Chiang, S Chen, J Liu… - Cell Death & …, 2022 - nature.com
Mesenchymal stem cells (MSCs) can be widely isolated from various tissues including bone
marrow, umbilical cord, and adipose tissue, with the potential for self-renewal and …

Reciprocal regulation of mesenchymal stem cells and immune responses

Y Wang, J Fang, B Liu, C Shao, Y Shi - Cell stem cell, 2022 - cell.com
Mesenchymal stem/stromal cells (MSCs) exist in almost all tissues and participate in tissue
regeneration and homeostasis. In-vitro-expanded MSCs are employed as therapeutics for …

Shattering barriers toward clinically meaningful MSC therapies

O Levy, R Kuai, EMJ Siren, D Bhere, Y Milton… - Science …, 2020 - science.org
More than 1050 clinical trials are registered at FDA. gov that explore multipotent
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …

Mesenchymal stromal cell therapies: immunomodulatory properties and clinical progress

X Wu, J Jiang, Z Gu, J Zhang, Y Chen, X Liu - Stem cell research & …, 2020 - Springer
Mesenchymal stromal cells (MSCs) are a subset of heterogeneous non-hematopoietic
fibroblast-like cells that can differentiate into cells of multiple lineages, such as …

Allogeneic vs. autologous mesenchymal stem/stromal cells in their medication practice

C Li, H Zhao, L Cheng, B Wang - Cell & Bioscience, 2021 - Springer
Mesenchymal stem/stromal cell (MSC)-based therapeutics is already available for treatment
of a range of diseases or medical conditions. Autologous or allogeneic MSCs obtained from …

Strategies for bone regeneration: from graft to tissue engineering

G Battafarano, M Rossi, V De Martino… - International journal of …, 2021 - mdpi.com
Bone is a regenerative organ characterized by self-renewal ability. Indeed, it is a very
dynamic tissue subjected to continuous remodeling in order to preserve its structure and …

[HTML][HTML] Multipotent stromal cells: one name, multiple identities

H Soliman, M Theret, W Scott, L Hill, TM Underhill… - Cell stem cell, 2021 - cell.com
Multipotent stromal cells (MSCs) are vital for development, maintenance, function, and
regeneration of most tissues. They can differentiate along multiple connective lineages, but …

Improved MSC minimal criteria to maximize patient safety: a call to embrace tissue factor and hemocompatibility assessment of MSC products

G Moll, JA Ankrum, SD Olson… - Stem cells translational …, 2022 - academic.oup.com
The number of mesenchymal stromal/stem cell (MSC) therapeutics and types of clinical
applications have greatly diversified during the past decade, including rapid growth of poorly …

Different sources of mesenchymal stem cells for tissue regeneration: a guide to identifying the most favorable one in orthopedics and dentistry applications

VJ Costela-Ruiz, L Melguizo-Rodríguez… - International Journal of …, 2022 - mdpi.com
The success of regenerative medicine in various clinical applications depends on the
appropriate selection of the source of mesenchymal stem cells (MSCs). Indeed, the source …

Mesenchymal stromal cell-based therapy for cartilage regeneration in knee osteoarthritis

XN Xiang, SY Zhu, HC He, X Yu, Y Xu… - Stem cell research & …, 2022 - Springer
Osteoarthritis, as a degenerative disease, is a common problem and results in high
socioeconomic costs and rates of disability. The most commonly affected joint is the knee …