Hemiindigoids comprise a range of natural and synthetic scaffolds that share the same
aromatic hydrocarbon backbone as well as promising biological and optical properties. The …

Binding free energy calculations are increasingly used in drug discovery research to predict
protein-ligand binding affinities and to prioritize candidate drug molecules accordingly. It has …

Anticoagulants prevent the blood from developing the coagulation process, which is the
primary cause of death in thromboembolic illnesses. Phenindione (PID) is a well-known …

Delphinium roylei Munz is an indigenous medicinal plant to India where its activity against
cancer has not been previously investigated, and its specific interactions of bioactive …

Acute myeloid leukemia (AML) is characterized by disruption of intracellular signaling due to
aberration of extracellular signaling pathways, namely PI3K/AKT cascade, by dysregulating …

Abstract Coronavirus disease 19 (COVID-19) is a severe acute respiratory syndrome caused
by SARS-CoV-2 (2019-nCoV). While no drugs have yet been approved to treat this disease …

Glycogen synthase kinase-3β (GSK3β) controls many physiological pathways, and is
implicated in many diseases including Alzheimer's and several cancers. GSK3β-mediated …

Cancer continues to be a major health concern globally, although the advent of targeted
therapy has revolutionized treatment options. Aurora Kinase B is a serine‐threonine kinase …

Gene fusions and point mutations of RET kinase are crucial for driving thoracic cancers,
including thyroid cancer and non-small cell lung cancer. Various scaffolds based on different …

Gastric cancers are caused primarily due to the activation and amplification of the EGFR or
HER2 kinases resulting in cell proliferation, adhesion, angiogenesis, and metastasis …