Nearly 60 CCCH zinc finger proteins have been identified in humans and mice. These
proteins are involved in the regulation of multiple steps of RNA metabolism, including mRNA …

RNA acts as an immunostimulatory molecule in the innate immune system to activate
nucleic acid sensors. It functions as an intermediate, conveying genetic information to …

RNA–protein interactions play numerous roles in cellular function and disease. Here we
describe RNA–protein interaction detection (RaPID), which uses proximity-dependent …

Regnase-1 and Roquin are RNA binding proteins essential for degradation of inflammation-
related mRNAs and maintenance of immune homeostasis. However, their mechanistic …

Humoral autoimmunity paralleled by the accumulation of follicular helper T cells (TFH cells)
is linked to mutation of the gene encoding the RNA-binding protein roquin-1. Here we found …

In all organisms, regulation of gene expression must be adjusted to meet cellular
requirements and frequently involves helix–turn–helix (HTH) domain proteins. For instance …

Constitutive activation of the MALT1 paracaspase in conventional T cells of Malt1 TBM/TBM
(TRAF6 Binding Mutant= TBM) mice causes fatal inflammation and autoimmunity, but the …

Roquin and Regnase-1 proteins bind and post-transcriptionally regulate proinflammatory
target messenger RNAs to maintain immune homeostasis. Either the sanroque mutation in …

Roquin proteins preclude spontaneous T cell activation and aberrant differentiation of T
follicular helper (Tfh) or T helper 17 (Th17) cells. Here we showed that deletion of Roquin …

Zinc finger (ZnF) domains appear in a pool of structural contexts and despite their small size
achieve varying target specificities, covering single-stranded and double-stranded DNA and …