The CD73/ado system—a new player in RT induced adverse late effects

S de Leve, F Wirsdörfer, V Jendrossek - Cancers, 2019 - mdpi.com
Radiotherapy (RT) is a central component of standard treatment for many cancer patients.
RT alone or in multimodal treatment strategies has a documented contribution to enhanced …

Gene signature of the post-Chernobyl papillary thyroid cancer

D Handkiewicz-Junak, M Swierniak, D Rusinek… - European journal of …, 2016 - Springer
Purpose Following the nuclear accidents in Chernobyl and later in Fukushima, the nuclear
community has been faced with important issues concerning how to search for and …

Age and sex effects across the blood proteome after ionizing radiation exposure can bias biomarker screening and risk assessment

B Langen, E Vorontsov, J Spetz, J Swanpalmer… - Scientific Reports, 2022 - nature.com
Molecular biomarkers of ionizing radiation (IR) exposure are a promising new tool in various
disciplines: they can give necessary information for adaptive treatment planning in cancer …

Long-term transcriptomic and proteomic effects in Sprague Dawley rat thyroid and plasma after internal low dose 131I exposure

M Larsson, N Rudqvist, J Spetz, E Shubbar, TZ Parris… - Plos one, 2020 - journals.plos.org
Background Radioiodide (131I) is commonly used to treat thyroid cancer and hyperthyroidis.
131I released during nuclear accidents, have resulted in increased incidence of thyroid …

Development of a machine learning framework for radiation biomarker discovery and absorbed dose prediction

B Andersson, B Langen, P Liu… - Frontiers in Oncology, 2023 - frontiersin.org
Background Molecular radiation biomarkers are an emerging tool in radiation research with
applications for cancer radiotherapy, radiation risk assessment, and even human space …

Occupational radiation exposure and changes in thyroid hormones in a cohort of Chinese medical radiation workers

QS Guo, R Ping, WX Huang, JC Qiu - Biomedical and Environmental …, 2021 - Elsevier
Objective This study aimed to evaluate the association between occupational radiation
exposure and changes in thyroid hormone levels among medical radiation workers …

Transcriptional response to 131I exposure of rat thyroid gland

N Rudqvist, J Spetz, E Schüler, TZ Parris, B Langen… - PLoS …, 2017 - journals.plos.org
Humans are exposed to 131I in medical diagnostics and treatment but also from nuclear
accidents, and better knowledge of the molecular response in thyroid is needed. The aim of …

Potential Biomarkers for Radiation-Induced Renal Toxicity following 177Lu-Octreotate Administration in Mice

E Schüler, M Larsson, TZ Parris, ME Johansson… - PLoS …, 2015 - journals.plos.org
The kidneys are one of the main dose-limiting organs in peptide receptor radionuclide
therapy and due to large inter-individual variations in renal toxicity, biomarkers are urgently …

Age-related long-term response in rat thyroid tissue and plasma after internal low dose exposure to 131I

M Larsson, NP Rudqvist, J Spetz, TZ Parris… - Scientific reports, 2022 - nature.com
Abstract 131I is used clinically for therapy, and may be released during nuclear accidents.
After the Chernobyl accident papillary thyroid carcinoma incidence increased in children, but …

Circadian rhythm influences genome-wide transcriptional responses to 131I in a tissue-specific manner in mice

B Langen, N Rudqvist, TZ Parris, K Helou… - EJNMMI research, 2015 - Springer
Background Circadian variation of gene expression is often neglected when ionizing
radiation-induced effects are studied, whether in animal models or in cell culture. This study …