Low expression levels and stoichiometric imbalances of long noncoding RNAs (lncRNAs)
are often used as evidence for their probable lack of function or for limiting the scope of their …

Esophageal squamous cell carcinoma (ESCC) is one of the most common human
malignancies worldwide and is associated with high morbidity and mortality. More than 70 …

The tumor stroma of pancreatic ductal adenocarcinoma (PDAC) is characterized by an
abundant and heterogeneous population of cancer-associated fibroblasts (CAFs), which are …

The protooncoprotein N-Myc, which is overexpressed in approximately 25% of
neuroblastomas as the consequence of MYCN gene amplification, has long been postulated …

DNA double-stranded breaks (DSBs) are a particularly challenging form of DNA damage to
repair because the damaged DNA must not only undergo the chemical reactions …

Abstract Background Cancer-associated fibroblasts (CAFs) play pivotal roles in
chemoresistance of pancreatic ductal adenocarcinoma (PDAC). However, the underlying …

Non-coding RNAs (ncRNAs) have diverse functions in health and pathology in many
tissues, including the liver. This review highlights important microRNAs (miRs), long non …

Long noncoding RNAs (lncRNAs) are products of pervasive transcription that closely
resemble messenger RNAs on the molecular level, yet function through largely unknown …

Hepatocellular carcinoma (HCC) presents a significant global health threat, particularly in
regions endemic to hepatitis B and C viruses, and because of the ongoing pandemic of …

The synapsis of DNA ends is a critical step for the repair of double-strand breaks by non-
homologous end joining (NHEJ). This is performed by a multicomponent protein complex …