Bone-tissue defects affect millions of people worldwide. Despite being common treatment
approaches, autologous and allogeneic bone grafting have not achieved the ideal …

Osteoarthritis (OA) is a degenerative joint disease in the elderly. Although OA has been
considered as primarily a disease of the articular cartilage, the participation of subchondral …

Blood vessels form a versatile transport network that is best known for its critical roles in
processes such as tissue oxygenation, metabolism and immune surveillance. The …

Angiogenesis, well-coupled with osteogenesis, plays an indispensable and vital role in
modulating hard tissue regeneration. Thus, simultaneously promoting osteogenesis and …

Abstract Prostaglandin E2 (PGE2), a major cyclooxygenase-2 (COX-2) product, is highly
secreted by the osteoblast lineage in the subchondral bone tissue of osteoarthritis (OA) …

Bone vasculature and bone marrow vascular niches supply oxygen, nutrients, and secrete
angiocrine factors required for the survival, maintenance, and self‐renewal of stem and …

Polyetheretherketone (PEEK) has been an alternative material for titanium in bone defect
repair, but its clinical application is limited by its poor osseointegration. In this study, a …

Recently, bone marrow endothelial cells (BMECs) were found to play an important role in
regulating bone homeostasis. However, few studies utilized BMECs to treat bone metabolic …

Accumulating evidence suggests that the therapeutic role of mesenchymal stem cells
(MSCs) in bone diseases is closely related to paracrine-generated extracellular vesicles …

Steroid-induced osteonecrosis of the femoral head (SONFH) is a disease characterized by
the collapse of the femoral head. SONFH occurs due to the overuse of glucocorticoids (GCs) …