[HTML][HTML] ALBI grade: Evidence for an improved model for liver functional estimation in patients with hepatocellular carcinoma

CO Demirtas, A D'Alessio, L Rimassa, R Sharma… - JHEP Reports, 2021 - Elsevier
Hepatocellular carcinoma (HCC) usually arises in the context of a chronically damaged liver.
Liver functional estimation is of paramount importance in clinical decision making. The Child …

[PDF][PDF] Progress and challenges of predictive biomarkers for immune checkpoint blockade

Y Lei, X Li, Q Huang, X Zheng, M Liu - Frontiers in Oncology, 2021 - frontiersin.org
Over the past decade, immune checkpoint blockade (ICB) therapy has revolutionized the
outlook for oncology with significant and sustained improvement in the overall patient …

[HTML][HTML] Gut microbiota and metabolites associate with outcomes of immune checkpoint inhibitor–treated unresectable hepatocellular carcinoma

PC Lee, CJ Wu, YW Hung, CJ Lee, CT Chi… - … for immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Background Immune checkpoint inhibitors (ICIs) are promising agents for unresectable
hepatocellular carcinoma (uHCC), but lack effective biomarker to predict outcomes. The gut …

Immunotherapy for hepatocellular carcinoma: recent advances and future targets

SJ Yu - Pharmacology & Therapeutics, 2023 - Elsevier
Immunotherapy is a promising approach to treating various types of cancers, including
hepatocellular carcinoma (HCC). While single immunotherapy drugs show limited …

Immune checkpoint inhibitors for child-pugh class B advanced hepatocellular carcinoma: a systematic review and meta-analysis

E Xie, YH Yeo, B Scheiner, Y Zhang, A Hiraoka… - JAMA …, 2023 - jamanetwork.com
Importance Immune checkpoint inhibitors (ICIs) are increasingly used in patients with
advanced hepatocellular carcinoma (HCC). However, data on ICI therapy in patients with …

[HTML][HTML] Management consensus guideline for hepatocellular carcinoma: 2020 update on surveillance, diagnosis, and systemic treatment by the Taiwan Liver Cancer …

YY Shao, SY Wang, SM Lin, KY Chen, JH Tseng… - Journal of the Formosan …, 2021 - Elsevier
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality in Taiwan.
The Taiwan Liver Cancer Association and the Gastroenterological Society of Taiwan had …

[HTML][HTML] Risk of HBV reactivation in patients with immune checkpoint inhibitor-treated unresectable hepatocellular carcinoma

PC Lee, Y Chao, MH Chen, KH Lan… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background Immunotherapy with immune checkpoint inhibitor (ICI) is a promising treatment
for unresectable hepatocellular carcinoma (HCC). However, whether ICIs would have the …

[HTML][HTML] Blood biomarkers predict outcomes in patients with hepatocellular carcinoma treated with immune checkpoint Inhibitors: A pooled analysis of 44 retrospective …

L Zhang, J Feng, T Kuang, D Chai, Z Qiu… - International …, 2023 - Elsevier
Objective We conducted the first meta-analysis to identify the predictive significance of
baseline blood biomarkers (such as neutrophil to lymphocyte ratio (NLR), early alpha …

Early experience of atezolizumab plus bevacizumab therapy in Japanese patients with unresectable hepatocellular carcinoma in real-world practice

Y Hayakawa, K Tsuchiya, M Kurosaki, Y Yasui… - Investigational new …, 2022 - Springer
Background. We aimed to investigate the efficacy and safety of atezolizumab plus
bevacizumab therapy in patients with unresectable hepatocellular carcinoma (u-HCC) …

Immunotherapy in hepatocellular cancer patients with mild to severe liver dysfunction: adjunctive role of the ALBI grade

DJ Pinato, T Kaneko, A Saeed, T Pressiani, A Kaseb… - Cancers, 2020 - mdpi.com
Immune checkpoint inhibitors (ICI) have shown positive results in patients with
hepatocellular carcinoma (HCC). As liver function contributes to prognosis, its precise …