Dietary fat provides essential nutrients, contributes to energy balance, and regulates blood
lipid concentrations. These functions are important to health, but can also become …

How do functional foods affect human health? To answer this question it is important to
understand what happens when food is digested and taken up by the gastrointestinal (GI) …

Microbiota influence diverse aspects of intestinal physiology and disease in part by
controlling tissue-specific transcription of host genes. However, host genomic mechanisms …

The nuclear receptor superfamily includes many receptors, identified based on their
similarity to steroid hormone receptors but without a known ligand. The study of how these …

The intestinal epithelium serves the unique and critical function of harvesting dietary
nutrients, while simultaneously acting as a cellular barrier separating tissues from the …

Enterocytes, the intestinal absorptive cells, have to deal with massive alimentary lipids upon
food consumption. They orchestrate complex lipid-trafficking events that lead to the secretion …

Today, it is well established that the development of obesity and associated diseases
results, in part, from excessive lipid intake associated with a qualitative imbalance. Among …

The worldwide prevalence of metabolic diseases is increasing, and there are global
recommendations to limit consumption of certain nutrients, especially saturated lipids …

Background & Aims The intestine constantly interprets and adapts to complex combinations
of dietary and microbial stimuli. However, the transcriptional strategies by which the …

Hepatocyte nuclear 4 alpha (HNF4α), involved in glucose and lipid metabolism, has been
linked to intestinal inflammation and abnormal mucosal permeability. Moreover, in a …