[HTML][HTML] Two-component regulatory systems in Helicobacter pylori and Campylobacter jejuni: Attractive targets for novel antibacterial drugs

J Casado, A Lanas, A González - Frontiers in Cellular and Infection …, 2022 - frontiersin.org
Two-component regulatory systems (TCRS) are ubiquitous signal transduction mechanisms
evolved by bacteria for sensing and adapting to the constant changes that occur in their …

Targeting of regulators as a promising approach in the search for novel antimicrobial agents

D Roncarati, V Scarlato, A Vannini - Microorganisms, 2022 - mdpi.com
Since the discovery of penicillin in the first half of the last century, antibiotics have become
the pillars of modern medicine for fighting bacterial infections. However, pathogens resistant …

Levofloxacin and Ciprofloxacin Co-Crystals with Flavonoids: Solid-State Investigation for a Multitarget Strategy against Helicobacter pylori

C Fiore, F Antoniciello, D Roncarati, V Scarlato… - Pharmaceutics, 2024 - mdpi.com
In this paper, we address the problem of antimicrobial resistance in the case of Helicobacter
pylori with a crystal engineering approach. Two antibiotics of the fluoroquinolone class …

Molecular insights into the fine-tuning of pH-dependent ArsR-mediated regulation of the SabA adhesin in Helicobacter pylori

A Åberg, P Gideonsson, A Bhat, P Ghosh… - Nucleic Acids …, 2024 - academic.oup.com
Adaptation to variations in pH is crucial for the ability of Helicobacter pylori to persist in the
human stomach. The acid responsive two-component system ArsRS, constitutes the global …

Engineering of Bacillus Promoters Based on Interacting Motifs between UP Elements and RNA Polymerase (RNAP) α-Subunit

Y Li, X Ma, L Zhang, Z Ding, S Xu, Z Gu… - International Journal of …, 2022 - mdpi.com
Bacillus genetics need more versatile promoters for gene circuit engineering. UP elements
are widely distributed in noncoding regions and interact with the α-subunit of RNA …

Targeting the Essential Transcription Factor HP1043 of Helicobacter pylori: A Drug Repositioning Study

F Antoniciello, D Roncarati, A Zannoni… - Frontiers in Molecular …, 2022 - frontiersin.org
Antibiotic-resistant bacterial pathogens are a very challenging problem nowadays.
Helicobacter pylori is one of the most widespread and successful human pathogens since it …

Bacterial Regulatory Proteins

J Kormanec - International Journal of Molecular Sciences, 2022 - mdpi.com
The regulation of gene expression in bacteria occurs predominantly at the level of
transcription, which is controlled by RNA polymerase. The specificity of this process is …

2nd Workshop in Microbial Molecular Biology.

CE Alvarez‐Martinez, M Brocchi… - Molecular …, 2023 - search.ebscohost.com
The" 2 SP nd sp Workshop in Microbial Molecular Biology" was the second edition of a
scientific meeting organized by the molecular microbiology community of São Paulo State …

Characterisation of RNase Y in H. pylori: a non-essential enzyme involved in the processing of cag-PAI non coding RNA 1 (CncR1) sRNA

F D'Agostino - 2023 - amsdottorato.unibo.it
The importance of Helicobacter pylori as a human pathogen is underlined by the plethora of
diseases it is responsible for. The capacity of H. pylori to adapt to the restricted host …

Targeting the Essential Transcription

F Antoniciello, D Roncarati, A Zannoni… - … of structural biology …, 2023 - books.google.com
Targeting the Essential Transcription Page 89 ORIGINAL RESEARCH published: 11 May 2022
doi: 10.3389/fmolb. 2022.887564 Targeting the Essential Transcription Factor HP1043 of …