Metabolic syndrome, autoimmunity and rheumatic diseases

G Medina, O Vera-Lastra, AL Peralta-Amaro… - Pharmacological …, 2018 - Elsevier
Metabolic syndrome (MetS) is a cluster of metabolic and cardiovascular (CV) risk factors
including obesity and visceral adiposity, insulin resistance, dyslipidemia and hypertension …

Systematic Review on the Role of IL-6 and IL-1β in Cardiovascular Diseases

N Katkenov, Z Mukhatayev, S Kozhakhmetov… - Journal of …, 2024 - mdpi.com
Cardiovascular diseases (CVDs) are a leading cause of global morbidity and mortality,
significantly driven by chronic inflammation. Interleukin-6 (IL-6) and interleukin-1β (IL-1β) …

Chronic kidney disease promotes atrial fibrillation via inflammasome pathway activation

J Song, JA Navarro-Garcia, J Wu… - The Journal of …, 2023 - Am Soc Clin Investig
Chronic kidney disease (CKD) is associated with a higher risk of atrial fibrillation (AF). The
mechanistic link between CKD and AF remains elusive. IL-1β, a main effector of NLR family …

The covalent NLRP3-inflammasome inhibitor Oridonin relieves myocardial infarction induced myocardial fibrosis and cardiac remodeling in mice

RF Gao, X Li, HY Xiang, H Yang, CY Lv, XL Sun… - International …, 2021 - Elsevier
Background Myocardial infarction (MI) triggers a strong inflammatory response that is
associated with myocardial fibrosis and cardiac remodeling. Interleukin (IL)-1β and IL-18 are …

Ferroptosis: a potential target in cardiovascular disease

Y Leng, X Luo, J Yu, H Jia, B Yu - Frontiers in Cell and …, 2022 - frontiersin.org
Ferroptosis is a new form of regulatory cell death characterized by iron-dependent and
intracellular lipid peroxidation. Ferroptosis can be divided into two stages. The first stage is …

Modulation of mTOR signaling in cardiovascular disease to target acute and chronic inflammation

M Kaldirim, A Lang, S Pfeiler, P Fiegenbaum… - Frontiers in …, 2022 - frontiersin.org
Inflammation is a key component in the pathogenesis of cardiovascular diseases causing a
significant burden of morbidity and mortality worldwide. Recent research shows that …

Parkinson's disease: a systemic inflammatory disease accompanied by bacterial inflammagens

B Adams, JM Nunes, MJ Page, T Roberts… - Frontiers in aging …, 2019 - frontiersin.org
Parkinson's disease (PD) is a well-known neurodegenerative disease with a strong
association established with systemic inflammation. Recently, the role of the gingipain …

Interleukin-1 in Coronary Artery Disease

E Oikonomou, P Tsaplaris, A Anastasiou… - Current Topics in …, 2022 - ingentaconnect.com
Cardiovascular disease is the leading cause of mortality worldwide. Inflammation has long
been established as a key component in the pathophysiology of coronary artery disease …

Lysophosphatidylcholine induces NLRP3 inflammasome-mediated foam cell formation and pyroptosis in human monocytes and endothelial cells

R Corrêa, LFF Silva, DJS Ribeiro, RN Almeida… - Frontiers in …, 2020 - frontiersin.org
Foam cells are specialized lipid-loaded macrophages derived from monocytes and are a
key pathological feature of atherosclerotic lesions. Lysophosphatidylcholine (LPC) is a …

Interleukin-1β in multifactorial hypertension: inflammation, vascular smooth muscle cell and extracellular matrix remodeling, and non-coding RNA regulation

E Melton, H Qiu - International Journal of Molecular Sciences, 2021 - mdpi.com
The biological activities of interleukins, a group of circulating cytokines, are linked to the
immuno-pathways involved in many diseases. Mounting evidence suggests that interleukin …