Multidrug resistance (MDR) is the phenomenon in which cancer cells simultaneously
develop resistance to a broad spectrum of structurally and mechanistically unrelated drugs …

CRS with nasal polyps (CRSwNP) is a multifactorial disease, and various etiological factors
like bacterial superantigens are known to develop this disease. Recent studies reported that …

ABC transporters play an essential role in the development of multidrug resistance and thus
are of interest in the context of anticancer therapy. However, MDR1, BCRP and MRP1 are …

Verapamil is a calcium channel blocker that holds promise for the therapy of chronic
rhinosinusitis (CRS) with and without nasal polyps. The verapamil-induced side effects limit …

Chronic rhinosinusitis (CRS) is a debilitating condition characterized by long-lasting
inflammation of the paranasal sinuses. It affects a significant portion of the population …

Objective P‐glycoprotein (P‐gp) drives type‐2 helper T‐cell inflammation in chronic
rhinosinusitis with nasal polyps (CRSwNP) through unknown posttranslational mechanisms …

Chronic rhinosinusitis (CRS) is a multifactorial and highly heterogeneous upper airway
disease that affects approximately 12% of the general population. There is increasing …

LETTERS TO THE EDITOR 271 verapamil HCl or placebo in blocks of 10 in a double-
blinded manner. Follow-up visits were scheduled at weeks 2, 4, and 8. The primary end …

Objective The discovery of noninvasive biomarkers of chronic rhinosinusitis (CRS) is critical
to enable our ability to provide prognostic information and targeted medical therapy …

Cystatin SN, encoded by CST1, belongs to the type 2 (T2) cystatin protein superfamily. In the
past decade, several publications have highlighted the association between cystatin SN and …