The redox states of the NAD and NADP pyridine nucleotide pools play critical roles in
defining the activity of energy producing pathways, in driving oxidative stress and in …

Semiconductor quantum dots (QDs) are brightly luminescent nanoparticles that have found
numerous applications in bioanalysis and bioimaging. In this review, we highlight recent …

NAD is a key determinant of cellular energy metabolism. In contrast, its phosphorylated form,
NADP, plays a central role in biosynthetic pathways and antioxidant defence. The reduced …

Fluorescence lifetime imaging (FLIM) is a key fluorescence microscopy technique to map the
environment and interaction of fluorescent probes. It can report on photophysical events that …

This article presents an overview of time-resolved (lifetime) fluorescence techniques used in
biomedical diagnostics. In particular, we review the development of time-resolved …

We demonstrate for the first time the application of an endoscopic fluorescence lifetime
imaging microscopy (FLIM) system to the intraoperative diagnosis of glioblastoma …

Fluorescence lifetime imaging (FLIm) is an optical spectroscopic imaging technique capable
of real‐time assessments of tissue properties in clinical settings. Label‐free FLIm is sensitive …

Minimally invasive, specific measurement of cellular energy metabolism is crucial for
understanding cerebral pathophysiology. Here, we present high-resolution, in vivo …

Optical imaging of tissue autofluorescence has the potential to provide rapid label-free
screening and detection of surface tumors for clinical applications, including when combined …

Non-linear optical (NLO) microscopy has proven to be a powerful tool especially for tissue
imaging with sub-cellular resolution, high penetration depth, endogenous contrast …