Genetics and epigenetics in obesity
K Rohde, M Keller, L la Cour Poulsen, M Blüher… - Metabolism, 2019 - Elsevier
Obesity is among the most threatening health burdens worldwide and its prevalence has
markedly increased over the last decades. Obesity maybe considered a heritable trait …
markedly increased over the last decades. Obesity maybe considered a heritable trait …
DNA methylation analysis: choosing the right method
S Kurdyukov, M Bullock - Biology, 2016 - mdpi.com
In the burgeoning field of epigenetics, there are several methods available to determine the
methylation status of DNA samples. However, choosing the method that is best suited to …
methylation status of DNA samples. However, choosing the method that is best suited to …
Genetic drivers of epigenetic and transcriptional variation in human immune cells
Characterizing the multifaceted contribution of genetic and epigenetic factors to disease
phenotypes is a major challenge in human genetics and medicine. We carried out high …
phenotypes is a major challenge in human genetics and medicine. We carried out high …
[HTML][HTML] The transcriptional landscape of age in human peripheral blood
MJ Peters, R Joehanes, LC Pilling… - Nature …, 2015 - nature.com
Disease incidences increase with age, but the molecular characteristics of ageing that lead
to increased disease susceptibility remain inadequately understood. Here we perform a …
to increased disease susceptibility remain inadequately understood. Here we perform a …
Osteogenesis depends on commissioning of a network of stem cell transcription factors that act as repressors of adipogenesis
Mesenchymal (stromal) stem cells (MSCs) constitute populations of mesodermal multipotent
cells involved in tissue regeneration and homeostasis in many different organs. Here we …
cells involved in tissue regeneration and homeostasis in many different organs. Here we …
[HTML][HTML] DNA methylation in the pathogenesis of type 2 diabetes in humans
Abstract Background Type 2 diabetes (T2D) is a multifactorial, polygenic disease caused by
impaired insulin secretion and insulin resistance. Genome-wide association studies (GWAS) …
impaired insulin secretion and insulin resistance. Genome-wide association studies (GWAS) …
Genetic regulatory signatures underlying islet gene expression and type 2 diabetes
Genome-wide association studies (GWAS) have identified> 100 independent SNPs that
modulate the risk of type 2 diabetes (T2D) and related traits. However, the pathogenic …
modulate the risk of type 2 diabetes (T2D) and related traits. However, the pathogenic …
Genome-wide CpG density and DNA methylation analysis method (MeDIP, RRBS, and WGBS) comparisons
D Beck, M Ben Maamar, MK Skinner - Epigenetics, 2022 - Taylor & Francis
Genome-wide DNA methylation analysis is one of the most common epigenetic processes
analysed for genome characterization and differential DNA methylation assessment …
analysed for genome characterization and differential DNA methylation assessment …
CD36 in atherosclerosis: pathophysiological mechanisms and therapeutic implications
K Tian, Y Xu, A Sahebkar, S Xu - Current atherosclerosis reports, 2020 - Springer
Abstract Purpose of Review Atherosclerosis is a chronic disease characterized by lipid
retention and inflammation in the artery wall. The retention and oxidation of low-density …
retention and inflammation in the artery wall. The retention and oxidation of low-density …
AMICO galaxy clusters in KiDS-DR3: Cosmological constraints from counts and stacked weak lensing
GF Lesci, F Marulli, L Moscardini, M Sereno… - Astronomy & …, 2022 - aanda.org
Aims. We present a cosmological analysis of abundances and stacked weak lensing profiles
of galaxy clusters, exploiting the AMICO KiDS-DR3 catalogue. The sample consists of 3652 …
of galaxy clusters, exploiting the AMICO KiDS-DR3 catalogue. The sample consists of 3652 …