Obesity is among the most threatening health burdens worldwide and its prevalence has
markedly increased over the last decades. Obesity maybe considered a heritable trait …

In the burgeoning field of epigenetics, there are several methods available to determine the
methylation status of DNA samples. However, choosing the method that is best suited to …

Characterizing the multifaceted contribution of genetic and epigenetic factors to disease
phenotypes is a major challenge in human genetics and medicine. We carried out high …

Disease incidences increase with age, but the molecular characteristics of ageing that lead
to increased disease susceptibility remain inadequately understood. Here we perform a …

Mesenchymal (stromal) stem cells (MSCs) constitute populations of mesodermal multipotent
cells involved in tissue regeneration and homeostasis in many different organs. Here we …

Abstract Background Type 2 diabetes (T2D) is a multifactorial, polygenic disease caused by
impaired insulin secretion and insulin resistance. Genome-wide association studies (GWAS) …

Genome-wide association studies (GWAS) have identified> 100 independent SNPs that
modulate the risk of type 2 diabetes (T2D) and related traits. However, the pathogenic …

Genome-wide DNA methylation analysis is one of the most common epigenetic processes
analysed for genome characterization and differential DNA methylation assessment …

Abstract Purpose of Review Atherosclerosis is a chronic disease characterized by lipid
retention and inflammation in the artery wall. The retention and oxidation of low-density …

Aims. We present a cosmological analysis of abundances and stacked weak lensing profiles
of galaxy clusters, exploiting the AMICO KiDS-DR3 catalogue. The sample consists of 3652 …