[HTML][HTML] Ras/Raf/MEK/ERK pathway activation in childhood acute lymphoblastic leukemia and its therapeutic targeting
T Knight, JAE Irving - Frontiers in oncology, 2014 - frontiersin.org
Deregulation of the Ras/Raf/MEK/extracellular signal-regulated kinase pathway is a
common event in childhood acute lymphoblastic leukemia and is caused by point mutation …
common event in childhood acute lymphoblastic leukemia and is caused by point mutation …
Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition
For most children who relapse with acute lymphoblastic leukemia (ALL), the prognosis is
poor, and there is a need for novel therapies to improve outcome. We screened samples …
poor, and there is a need for novel therapies to improve outcome. We screened samples …
[PDF][PDF] FLT3 Gene involvement in B-cell acute lymphoblastic leukemia (B-ALL)
A Okabe, F Guirales, D Zhao, CA Tirado - J Assoc Genet Technol, 2021 - researchgate.net
The FMS-like tyrosine kinase 3 gene (FLT3) is a receptor tyrosine kinase expressed in early
hematopoietic progenitors that play an important role in hematopoietic development. The …
hematopoietic progenitors that play an important role in hematopoietic development. The …
[HTML][HTML] Genetic mutational analysis of pediatric acute lymphoblastic leukemia from a single center in China using exon sequencing
H Zhang, H Wang, X Qian, S Gao, J Xia, J Liu, Y Cheng… - BMC cancer, 2020 - Springer
Background Acute lymphoblastic leukemia (ALL), the most common childhood malignancy,
is characterized by recurring structural chromosomal alterations and genetic alterations …
is characterized by recurring structural chromosomal alterations and genetic alterations …
[HTML][HTML] The frequency of NPM1 mutations in childhood acute myeloid leukemia
M Braoudaki, C Papathanassiou, K Katsibardi… - Journal of Hematology & …, 2010 - Springer
Background Mutations in the nucleophosmin (NPM1) gene have been solely associated
with childhood acute myeloid leukemia (AML). We evaluated the frequency of NPM1 …
with childhood acute myeloid leukemia (AML). We evaluated the frequency of NPM1 …
[HTML][HTML] FLT3mutation incidence and timing of origin in a population case series of pediatric leukemia
P Chang, M Kang, A Xiao, J Chang, J Feusner… - BMC cancer, 2010 - Springer
Background Mutations in FLT3 result in activated tyrosine kinase activity, cell growth
stimulation, and a poor prognosis among various subtypes of leukemia. The causes and …
stimulation, and a poor prognosis among various subtypes of leukemia. The causes and …
Proteomic analysis of childhood de novo acute myeloid leukemia and myelodysplastic syndrome/AML: correlation to molecular and cytogenetic analyses
M Braoudaki, F Tzortzatou-Stathopoulou… - Amino acids, 2011 - Springer
The aim of this study was to investigate the progression of myelodysplastic syndrome (MDS)
to acute myeloid leukemia (AML) and to provide additional data regarding the proteomic …
to acute myeloid leukemia (AML) and to provide additional data regarding the proteomic …
[HTML][HTML] FLT3 is implicated in cytarabine transport by human equilibrative nucleoside transporter 1 in pediatric acute leukemia
A Català, M Pastor-Anglada, L Caviedes-Cárdenas… - Oncotarget, 2016 - ncbi.nlm.nih.gov
FLT3 abnormalities are negative prognostic markers in acute leukemia. Infant leukemias are
a subgroup with frequent MLL (KMT2A) rearrangements, FLT3 overexpression and high …
a subgroup with frequent MLL (KMT2A) rearrangements, FLT3 overexpression and high …
[HTML][HTML] FLT3 internal tandem duplication and D835 mutations in patients with acute lymphoblastic leukemia and its clinical significance
G Elyamany, M Awad, O Alsuhaibani… - … journal of hematology …, 2014 - ncbi.nlm.nih.gov
FLT3 Internal Tandem Duplication and D835 Mutations in Patients with Acute Lymphoblastic
Leukemia and its Clinical Significance - PMC Back to Top Skip to main content NIH NLM Logo …
Leukemia and its Clinical Significance - PMC Back to Top Skip to main content NIH NLM Logo …
Sequential monitoring of minimal residual disease in acute lymphoblastic leukemia: 7-year experience in a pediatric hematology/oncology unit
We evaluated minimal residual disease (MRD) in 91 children with acute lymphoblastic
leukemia (ALL) by PCR amplification of clonal rearrangements, immunoglobulin (IgH; VDJ …
leukemia (ALL) by PCR amplification of clonal rearrangements, immunoglobulin (IgH; VDJ …