A novel domain (the BRICHOS domain) of∼ 100 amino acids has been identified in several
previously unrelated proteins that are linked to major diseases. These include BRI 2, which …

During the past year, computational methods have been developed that use the rapidly
accumulating genomic data to discover protein function. The methods rely on properties …

Sequence alignments unambiguously distinguish between protein pairs of similar and non-
similar structure when the pairwise sequence identity is high (> 40% for long alignments) …

MOTIVATION: A new hidden Markov model method (SAM-T98) for finding remote homologs
of protein sequences is described and evaluated. The method begins with a single target …

We are beginning to elucidate transcriptional regulatory networks on a large scale and to
understand some of the structural principles of these networks,, but the evolutionary …

Structural biology has the potential to illuminate the evolution of pathogen effectors and their
commonalities that cannot be readily detected at the primary sequence level. Recent …

The widening gap between known protein sequences and their functions has led to the
practice of assigning a potential function to a protein on the basis of sequence similarity to …

The sequences of related proteins can diverge beyond the point where their relationship can
be recognised by pairwise sequence comparisons. In attempts to overcome this limitation …

Distant homologies between proteins are often discovered only after three‐dimensional
structures of both proteins are solved. The sequence divergence for such proteins can be so …

Measuring in a quantitative, statistical sense the degree to which structural and functional
information can be “transferred” between pairs of related protein sequences at various levels …