The target of rapamycin (TOR), discovered 30 years ago, is a highly conserved
serine/threonine protein kinase that plays a central role in regulating cell growth and …

Breast cancer is a serious health problem worldwide, representing the second cause of
death through malignancies among women in developed countries. Population …

Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …

The mammalian or mechanistic target of rapamycin (mTOR) pathway plays a crucial role in
regulation of cell survival, metabolism, growth and protein synthesis in response to upstream …

The Ser and Thr kinase AKT, also known as protein kinase B (PKB), was discovered 25
years ago and has been the focus of tens of thousands of studies in diverse fields of biology …

The aim of this review was to summarize current available information about the role of
phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling …

Mechanistic target of rapamycin (mTOR) is a protein kinase regulating cell growth, survival,
metabolism, and immunity. mTOR is usually assembled into several complexes such as …

Type 2 diabetes mellitus is a widespread medical condition, characterized by high blood
glucose and inadequate insulin action, which leads to insulin resistance. Insulin resistance …

Since the discovery that rapamycin, a small molecule inhibitor of the protein kinase mTOR
(mechanistic target of rapamycin), can extend the lifespan of model organisms including …

The mammalian target of rapamycin, mTOR is the master regulator of a cell's growth and
metabolic state in response to nutrients, growth factors and many extracellular cues. Its …