Puromycin is a naturally occurring aminonucleoside antibiotic that inhibits protein synthesis
by ribosome-catalyzed incorporation into the C-terminus of elongating nascent chains …

Following the discovery of penicillin, which was inactive against Mycobacterium
tuberculosis, Waksman discovered the first antituberculosis agent, streptomycin, by …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

Our studies on the biochemical basis of spontaneous mutations took an interesting and
unexpected turn when we discovered that a small region of amino acid homology between …

Natural-product-derived cytotoxics remain a mainstay in current chemotherapy. 1 This
review focuses on the current level of understanding and emerging trends relevant to the …

Evolutionarily conserved mechanisms that control aging are predicted to have
prereproductive functions in order to be subject to natural selection. Genes that are essential …

Background: The ansamycin class of antibiotics are produced by various Actinomycetes.
Their carbon framework arises from the polyketide pathway via a polyketide synthase (PKS) …

The biosynthetic gene cluster for the enediyne antitumor antibiotic maduropeptin (MDP) from
Actinomadura madurae ATCC 39144 was cloned and sequenced. Cloning of the mdp gene …

Translation is an elementary cellular process that involves a large number of factors
interacting in a concerted fashion with the ribosome. Numerous natural products have …

Many microbes synthesize potentially autotoxic antibiotics, mainly as secondary metabolites,
against which they need to protect themselves. This is done in various ways, ranging from …