Complexes of ruthenium (II) as promising dual-active agents against cancer and viral infections
Poor responses to medical care and the failure of pharmacological treatment for many high-
frequency diseases, such as cancer and viral infections, have been widely documented. In …
frequency diseases, such as cancer and viral infections, have been widely documented. In …
Triarylphosphine-coordinated bipyridyl Ru (II) complexes induce mitochondrial dysfunction
RJ Mitchell, AS Gowda, AG Olivelli… - Inorganic …, 2023 - ACS Publications
While cancer cells rely heavily upon glycolysis to meet their energetic needs, reducing the
importance of mitochondrial oxidative respiration processes, more recent studies have …
importance of mitochondrial oxidative respiration processes, more recent studies have …
Synthesis and anticancer mechanisms of zinc (II)-8-hydroxyquinoline complexes with 1, 10-phenanthroline ancillary ligands
LQ Du, TY Zhang, XM Huang, Y Xu, MX Tan… - Dalton …, 2023 - pubs.rsc.org
Twenty new zinc (II) complexes with 8-hydroxyquinoline (H-Q1–H-Q6) in the presence of 1,
10-phenanthroline derivatives (D1–D10) were synthesized and formulated as [Zn (Q1) 2 …
10-phenanthroline derivatives (D1–D10) were synthesized and formulated as [Zn (Q1) 2 …
Antitumor studies evaluation of triphenylphosphine ruthenium complexes with 5, 7-dihalo-substituted-8-quinolinoline targeting mitophagy pathways
ZF Wang, XQ Huang, RC Wu, Y Xiao… - Journal of Inorganic …, 2023 - Elsevier
Both ruthenium-containing complexes and 8-quinolinoline compounds have emerged as a
potential novel agent for malignant tumor therapy. Here, three triphenylphosphine ruthenium …
potential novel agent for malignant tumor therapy. Here, three triphenylphosphine ruthenium …
Synthesis, RNA-sequence and evaluation of anticancer efficacy of ruthenium (II) polypyridyl complexes toward HepG2 cells
H Hu, H Zhang, R Zhong, Y Yang, C Huang… - Journal of Inorganic …, 2023 - Elsevier
In this article, four new Ru (II) complexes [Ru (dmbpy) 2 (TFBIP)](PF 6) 2 (dmbpy= 4, 4′-
dimethyl-2, 2′-bipyridine, TFPIP= 2-(4′-trifluoromethyl)-[1, 1′-biphenyl]-4-yl)-1H-imidazo …
dimethyl-2, 2′-bipyridine, TFPIP= 2-(4′-trifluoromethyl)-[1, 1′-biphenyl]-4-yl)-1H-imidazo …
Anticancer potential of diruthenium complexes with bridging hydrocarbyl ligands from bioactive alkynols
G Bresciani, J Vančo, T Funaioli, S Zacchini… - Inorganic …, 2023 - ACS Publications
Diruthenacyclopentenone complexes of the general composition [Ru2Cp2 (CO) 2 {μ–η1: η3-
CH═ C (C (OH)(R)) C (═ O)}](2a–c; Cp= η5-C5H5) were synthesized in 94–96% yields …
CH═ C (C (OH)(R)) C (═ O)}](2a–c; Cp= η5-C5H5) were synthesized in 94–96% yields …
A fluorogenic inhibitor of the mitochondrial calcium uniporter
Z Huang, SN MacMillan… - Angewandte Chemie …, 2023 - Wiley Online Library
Inhibitors of the mitochondrial calcium uniporter (MCU) are valuable tools for studying the
role of mitochondrial Ca2+ in various pathophysiological conditions. In this study, a new …
role of mitochondrial Ca2+ in various pathophysiological conditions. In this study, a new …
Single crystal investigation, spectroscopic, DFT studies, and in-silico molecular docking of the anticancer activities of acetylacetone coordinated Re (I) tricarbonyl …
ALE Manicum, H Louis, GE Mathias, EC Agwamba… - Inorganica Chimica …, 2023 - Elsevier
Acetylacetone was used in the synthesis of the neutral complexes, fac-[Re (Acac)(CO) 3 (1,
2-DiCH 3 Im)](Re-1) and fac-[Re (Acac)(CO) 3 (2-CH 3 Im)](Re-2), incorporating the (2+ 1) …
2-DiCH 3 Im)](Re-1) and fac-[Re (Acac)(CO) 3 (2-CH 3 Im)](Re-2), incorporating the (2+ 1) …
Carboxylate-Capped Analogues of Ru265 Are MCU Inhibitor Prodrugs
The mitochondrial calcium uniporter (MCU) is a transmembrane protein that resides on the
inner membrane of the mitochondria and mediates calcium uptake into this organelle. Given …
inner membrane of the mitochondria and mediates calcium uptake into this organelle. Given …
Cyclometalated Ru (ii)–NHC complexes with phenanthroline ligands induce apoptosis mediated by mitochondria and endoplasmic reticulum stress in cancer cells
C Chen, H Lv, H Xu, D Zhu, C Shen - Dalton Transactions, 2023 - pubs.rsc.org
The exploration of ruthenium complexes as anticancer drugs has been the focus of intense
investigation. In this study, we synthesized and characterized four C, N-cyclometalated …
investigation. In this study, we synthesized and characterized four C, N-cyclometalated …