The fat body plays major roles in the life of insects. It is a dynamic tissue involved in multiple
metabolic functions. One of these functions is to store and release energy in response to the …

Lipid metabolism is fundamental to life. In insects, it is critical, during reproduction, flight,
starvation, and diapause. The coordination center for insect lipid metabolism is the fat body …

The PAT family of lipid droplet proteins includes 5 members in mammals: perilipin, adipose
differentiation-related protein (ADRP), tail-interacting protein of 47 kDa (TIP47), S3–12, and …

The majority of eukaryotic cells synthesize neutral lipids and package them into cytosolic
lipid droplets. In vertebrates, triacylglycerol-rich lipid droplets of adipocytes provide a major …

During the past decade, there has been a paradigm shift in our understanding of the roles of
intracellular lipid droplets (LDs). New genetic, biochemical and imaging technologies have …

Organisms adapt to changing environments by adjusting their development, metabolism,
and behavior to improve their chances of survival and reproduction. To achieve such …

Energy homeostasis, a fundamental property of all organisms, depends on the ability to
control the storage and mobilization of fat, mainly triacylglycerols (TAG), in special organs …

The PAT family of proteins has been identified in eukaryotic species as diverse as
vertebrates, insects, and amebazoa. These proteins share a highly conserved sequence …

The discovery by Dr. Constantine Londos of perilipin 1, the major scaffold protein at the
surface of cytosolic lipid droplets in adipocytes, marked a fundamental conceptual change in …

The past few years have seen a shift in the use of Drosophila, from studies of growth and
development toward genetic characterization of carbohydrate, sterol, and lipid metabolism …