Lysine acetylation is a conserved, reversible, post-translational protein modification
regulated by lysine acetyltransferases (KATs) and lysine deacetylases (KDACs; also known …

Cardiovascular disease (CVD) is the leading cause of death in the world. Hypertension is a
serious medical problem not only in adults but also in children and adolescents. The renin …

After initial strategies targeting inotropism and congestion, the neurohormonal interpretative
model of heart failure (HF) pathophysiology has set the basis for current pharmacological …

The AT 1 receptor, a major effector of the renin-angiotensin system, has been extensively
studied in the context of cardiovascular and renal disease. Moreover, angiotensin receptor …

The renin–angiotensin system (RAS) is undisputedly well-studied as one of the oldest and
most critical regulators for arterial blood pressure, fluid volume, as well as renal function. In …

Healthy vascular endothelial cells regulate vascular tone and permeability, prevent vessel
wall inflammation, enhance thromboresistance, and contribute to general vascular health …

All the components of the classic renin–angiotensin system (RAS) have been identified in
the brain. Today, the RAS is considered to be composed mainly of two axes: the pressor …

Monocyte and adhesion infiltration into the arterial subendothelium are initial steps in
hypertension development. The endothelial intercellular adhesion molecule-1 (ICAM-1) has …

Abstract Angiotensin-(1–9)[Ang-(1–9)] is a peptide of the non-canonical renin-angiotensin
system (RAS) synthesized from angiotensin I by the monopeptidase angiotensin-converting …

Diabetes significantly affects the life quality and length of patients with diabetes, and almost
half of the 4 million people who die from diabetes are under the age of 60. Because of the …