Since nuclear factor of activated T cells (NFAT) was first identified as a transcription factor in
T cells, various NFAT isoforms have been discovered and investigated. Accumulating …

Similar to peripheral immune/inflammatory cells, neuroglial cells appear to rely on
calcineurin (CN) signaling pathways to regulate cytokine production and cellular activation …

Abdominal aortic aneurysms (AAA) are characterized by extensive extracellular matrix
(ECM) fragmentation and inflammation. However, the mechanisms by which these events …

The Wnt signaling pathway plays a crucial role in neurodevelopment and in regulating the
function and structure of the adult nervous system. Schizophrenia (SCZ) and bipolar …

Brain metastasis is a defining component of tumor pathophysiology, and the underlying
mechanisms responsible for this phenomenon are not well understood. Current dogma is …

The ongoing epidemics of metabolic diseases and increase in the older population have
increased the incidences of neurodegenerative diseases. Evidence from murine and cell …

Mounting evidence supports a fundamental role for Ca2+ dysregulation in astrocyte
activation. Though the activated astrocyte phenotype is complex, cell-type targeting …

Vascular contributions to cognitive impairment and dementia (VCID) is understood to be the
second most common cause of dementia after Alzheimer's disease, and is also a frequent …

Increasing evidence suggests that the calcineurin (CN)-dependent transcription factor NFAT
(Nuclear Factor of Activated T cells) mediates deleterious effects of astrocytes in progressive …

Ischemic brain injury inflicted by stroke and cardiac arrest ranks among the leading causes
of death and long-term disability in the United States. The brain consumes large amounts of …