The initial steps in the pathogenesis of atherosclerosis involve changes to the vascular
endothelium, which produces numerous substances involved in the regulation and …

The role of inflammation in cardiovascular disease and in hypertensive disease above all, is
complex. Several studies confirm that activation of renin-angiotensin-aldosteron system …

Hypertension is an established risk factor for cognitive decline and dementia in older adults,
highlighting the potential importance of antihypertensive treatments in prevention efforts …

BACKGROUND: Essential hypertension is associated with enhanced LDL oxidation and
impaired endothelium-dependent vasodilation. The antioxidant status is linked to the nitric …

Zofenopril, a new potent sulphydryl angiotensin-converting enzyme (ACE) inhibitor, is
characterized by high lipophilicity, selective cardiac ACE inhibition, and antioxidant and …

Atherosclerosis is a chronic inflammatory process. The adhesion of leukocytes to the
vascular endothelium, mediated by endothelial cell adhesion molecules including vascular …

Objective Data from prospective studies suggest a significant reduction in the risk of new
diabetes from drug therapies containing angiotensin-converting enzyme (ACE) inhibitors …

Background: Oxidative inactivation of nitric oxide (NO) is regarded as an important cause of
reduced endothelium-dependent vasodilation in essential hypertension. Because …

BACKGROUND: The aim of the study was to investigate the cardioprotective effects of the
angiotensin-converting enzyme inhibitor zofenopril in post–myocardial infarction (MI) …

The β-blocker nebivolol is a racemic mixture of d-and l-enantiomers that displays negative
inotropic as well as direct vasorelaxant activity. In addition, it has been proposed that …