Schizophrenia is associated with substantial unmet needs, highlighting the necessity for
new treatments. This narrative review compares the pharmacology, clinical trial data and …

Second generation antipsychotics (SGAs) are effective options in the treatment of
schizophrenia and mood disorders, each with characteristic efficacy and safety features. In …

Objective: The dose-response relationships of antipsychotic drugs for schizophrenia are not
well defined, but such information would be important for decision making by clinicians. The …

Schizophrenia is characterized by positive, negative, cognitive, and affective symptoms.
Antipsychotic medications, which work by blocking the dopamine D 2 receptor, are the …

Objective: To investigate the association of metabolic side effects with antipsychotic dose,
we conducted a dose-response meta-analysis of randomized controlled trials (RCTs) in …

Determining the optimal antipsychotic target dose in acute phase treatment is of high clinical
relevance. The effect of antipsychotics on negative symptoms should be taken into account …

Abstract Purpose of Review Over the last ten years, the treatment of psychosis has seen a
near explosion of creative development in both novel agents and new delivery modalities …

Dopamine receptors (DR) have been extensively studied, but only in recent years they
became object of investigation to elucidate the specific role of different subtypes (D1R, D2R …

The causal mechanisms and treatment for the negative symptoms and cognitive dysfunction
in schizophrenia are the main issues attracting the attention of psychiatrists over the last …

Purpose/Background Activating and sedating adverse effects of antipsychotics can be
obstacles to their use. Methods/Procedures This study quantified the activating and sedating …