Abstract Interleukin-6 (IL-6) plays a crucial role in host defense against infection and tissue
injuries and is a bioindicator of multiple distinct types of cytokine storms. In this review, we …

Interleukin-6 (IL-6) is a pleiotropic cytokine with roles in immunity, tissue regeneration, and
metabolism. Rapid production of IL-6 contributes to host defense during infection and tissue …

The diverse biological activity of interleukin-6 (IL-6) contributes to the maintenance of
homeostasis. Emergent infection or tissue injury induces rapid production of IL-6 and …

Since the molecular cloning of interleukin-6 (IL-6) in 1986, many other cytokines have been
found to share the same signal transducer, gp130, in their receptor complexes. Thus, the IL …

Castleman disease (CD), a heterogeneous group of disorders that share morphological
features, is divided into unicentric CD and multicentric CD (MCD) according to the clinical …

Publisher Summary This chapter focuses on structure and expression of interleukin-6 (IL-6),
which is a cytokine with pleiotropic activities that plays a central role in host defense. IL-6 …

Interleukin-6 (IL-6) is a proinflammatory cytokine that is normally tightly regulated and
expressed at low levels, except during infection, trauma, or other stress. Among several …

Abstract 5q–syndrome is a subtype of myelodysplastic syndrome characterized by severe
anemia and variable neutropenia but normal or high platelet counts with dysplastic …

Multicentric Castleman's disease (MCD) describes a heterogeneous group of disorders
involving proliferation of morphologically benign lymphocytes due to excessive …

Interleukin-6, an inflammatory cytokine, is characterized by pleiotropy and redundancy of
action. Apart from its hematologic, immune, and hepatic effects, it has many endocrine and …