Small molecule inhibitors of protein kinase D: early development, current approaches, and future directions
QJ Wang, P Wipf - Journal of medicinal chemistry, 2022 - ACS Publications
Now entering its fourth decade, research on the biological function, small molecule
inhibition, and disease relevance of the three known isoforms of protein kinase D, PKD1 …
inhibition, and disease relevance of the three known isoforms of protein kinase D, PKD1 …
Small-molecule inhibitor targeting protein kinase D: a potential therapeutic strategy
D Lv, H Chen, Y Feng, B Cui, Y Kang, P Zhang… - Frontiers in …, 2021 - frontiersin.org
The protein kinase D (PKD) family is a family of serine-threonine kinases that are members
of the calcium/calmodulin-dependent kinase (CaMK) superfamily. PKDs have been …
of the calcium/calmodulin-dependent kinase (CaMK) superfamily. PKDs have been …
Synthesis of N‐alkylated pyrazolo[3,4‐d]pyrimidine analogs and evaluation of acetylcholinesterase and carbonic anhydrase inhibition properties
Abstract Fused pyrimidines, especially pyrazolo [3, 4‐d] pyrimidines, are among the most
preferred building blocks for pharmacology studies, as they exhibit a broad spectrum of …
preferred building blocks for pharmacology studies, as they exhibit a broad spectrum of …
ZNL0325, a Pyrazolopyrimidine-Based Covalent Probe, Demonstrates an Alternative Binding Mode for Kinases
The pyrazolopyrimidine (PP) heterocycle is a versatile and widely deployed core scaffold for
the development of kinase inhibitors. Typically, a 4-amino-substituted pyrazolopyrimidine …
the development of kinase inhibitors. Typically, a 4-amino-substituted pyrazolopyrimidine …
Design, synthesis and biological evaluation of pyrazolo [3, 4-d] pyrimidine-based protein kinase D inhibitors
P Gilles, RS Kashyap, MJ Freitas, S Ceusters… - European Journal of …, 2020 - Elsevier
The multiple roles of protein kinase D (PKD) in various cancer hallmarks have been
repeatedly reported. Therefore, the search for novel PKD inhibitors and their evaluation as …
repeatedly reported. Therefore, the search for novel PKD inhibitors and their evaluation as …
Synthesis and in vitro antibacterial evaluation of 6-substituted 4-amino-pyrazolo[3,4-d]pyrimidines
Abstract Pyrazolo [3, 4-d] pyrimidines are one of the most important classes of fused
heterocyclic compounds which exhibit a broad range of biological and medicinal properties …
heterocyclic compounds which exhibit a broad range of biological and medicinal properties …
Developments in the discovery and design of protein kinase D inhibitors
P Gilles, L Voets, J Van Lint… - …, 2021 - Wiley Online Library
Protein kinase D (PKD) is a serine/threonine kinase family belonging to the
Ca2+/calmodulin‐dependent protein kinase group. Since its discovery two decades ago …
Ca2+/calmodulin‐dependent protein kinase group. Since its discovery two decades ago …
Novel pyrazolo[3,4‐d]pyrimidine derivatives inhibit human cancer cell proliferation and induce apoptosis by ROS generation
S Gaonkar, MA Savanur, AQA Nadaf… - Archiv der …, 2020 - Wiley Online Library
The paucity of effective anticancer drugs for successful treatment is a major concern,
indicating the strong need for novel therapeutic compounds. In the quest of new molecules …
indicating the strong need for novel therapeutic compounds. In the quest of new molecules …
[HTML][HTML] Discovery of pyrazolo [3, 4-d] pyrimidines as novel mitogen-activated protein kinase kinase 3 (MKK3) inhibitors
JE Takarada, MR Cunha, VM Almeida… - Bioorganic & Medicinal …, 2024 - Elsevier
The dual-specificity protein kinase MKK3 has been implicated in tumor cell proliferation and
survival, yet its precise role in cancer remains inconclusive. A critical step in elucidating the …
survival, yet its precise role in cancer remains inconclusive. A critical step in elucidating the …
Demystifying chronic kidney disease of unknown etiology (CKDu): computational interaction analysis of pesticides and metabolites with vital renal enzymes
Chronic kidney disease of unknown etiology (CKDu) has been recognized as a global non-
communicable health issue. There are many proposed risk factors for CKDu and the exact …
communicable health issue. There are many proposed risk factors for CKDu and the exact …