Advances in carbohydrate chemistry have certainly made common oligosaccharides much
more accessible. However, many current methods still rely heavily upon specialized …

This review is the sixth update of the original article published in 1999 on the application of
MALDI mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings …

We have explored the fundamental biological processes by which complex carbohydrates
expressed on cellular glycoproteins and glycolipids and in secretions of cells promote cell …

Blockade of P-selectin (P-sel)/PSGL-1 interactions holds significant potential for treatment of
disorders of innate immunity, thrombosis and cancer. Current inhibitors remain limited due to …

Sphingolipids are a structurally diverse class of lipids predominantly found in the plasma
membrane of eukaryotic cells. These lipids can laterally segregate with other rigid lipids and …

Reported herein is the development of a user-friendly platform for simple and transformative
automation based on standard HPLC equipment. We showcase how the improved platform …

The development of a useful methodology for simple, scalable, and transformative
automation of oligosaccharide synthesis that easily interfaces with existing methods is …

Purpose To assess whether the newly designed small-molecule oral P-selectin inhibitor 3 S-
1, 2, 3, 4-tetrahydro-β-carboline-3-methyl aspartyl ester (THCMA) as a nanomedicine …

A diversity-oriented chemoenzymatic approach for the collective preparation of sulfated core
2 O-GalNAc glycans and their nonsulfated counterparts was described. A sulfated …

Obesity-induced insulin resistance and metabolic syndrome continue to pose an important
public health challenge worldwide as they significantly increase the risk of type 2 diabetes …