Despite the widespread use of antineoplastic platinum drugs, a number of accompanying
disadvantages exist. In connection with attempts to circumvent these problems new platinum …

Chemotherapy, surgery and radiotherapy continue to be the mainstay treatments of cancer.
Over 700 FDA-approved drugs have entered into clinical practice during the last 30 years …

Since the antitumor activity of cisplatin was discovered in 1967 by Rosenberg, platinum-
based anticancer drugs have played an important role in chemotherapy in clinic …

Interactions between platinum complexes and human serum albumin (HSA) play crucial
roles in the metabolism, distribution, and efficacy of platinum-based anticancer drugs …

The development of bifunctional platinum complexes with the ability to interact with DNA via
different binding modes is of interest in anticancer metallodrug research. Therefore, we …

The ideal drug discovery process of new platinum based drugs should take into account
three basic fundaments: on one side the mechanisms of action and the corresponding target …

Metal complexes afford an opportunity for the discovery of new antitumour drugs with truly
novel mechanisms of action. Various tactics and some new concepts have been employed …

Cellular uptake of platinum-based antitumor drugs is a critical step in the mechanism of the
drug action and associated resistance, and deeper understanding of this step may inspire …

Platinum-based anticancer chemotherapy constitutes a cornerstone for the treatment of
various solid tumors. However, existing platinum drugs like cisplatin encounter many …

Despite numerous studies that report the glucose derived glycoconjugates as antitumor
candidates, using mannose as sugar motif for specific tumor targeting remains less studied …