The distribution of fitness effects (DFE) of new mutations is a fundamental entity in genetics
that has implications ranging from the genetic basis of complex disease to the stability of the …

Data on the effects of inbreeding on fitness components are reviewed in the light of
population genetic models of the possible genetic causes of inbreeding depression …

Renowned evolutionary biologists Peter and Rosemary Grant have produced landmark
studies of the Galápagos finches first made famous by Charles Darwin. In How and Why …

In the last decade, genomic selection has become a standard in the genetic evaluation of
livestock populations. However, most procedures for the implementation of genomic …

Mutation accumulation (MA) experiments, in which mutations are allowed to drift to fixation in
inbred lines, have been a principal way of studying the rates and properties of new …

Sex and recombination are widespread, but explaining these phenomena has been one of
the most difficult problems in evolutionary biology. Recombination is advantageous when …

Empirical studies of quantitative genetic variation have revealed robust patterns that are
observed both across traits and across species. However, these patterns have no …

Mutations spawn genetic variation which, in turn, fuels evolution. Hence, experimental
investigations into the rate and fitness effects of spontaneous mutations are central to the …

Background The availability of genome-wide marker data allows estimation of inbreeding
coefficients (F, the probability of identity-by-descent, IBD) and, in turn, estimation of the rate …

A multilocus stochastic model is developed to simulate the dynamics of mutational load in
small populations of various sizes. Old mutations sampled from a large ancestral population …