5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease
Lipoxygenase (5-LOX) catalyzes two steps in the biosynthesis of leukotrienes (LTs), lipid
mediators of inflammation derived from arachidonic acid. In this review we focus on 5-LOX …
mediators of inflammation derived from arachidonic acid. In this review we focus on 5-LOX …
Pyrrolizidine alkaloids—genotoxicity, metabolism enzymes, metabolic activation, and mechanisms
Pyrrolizidine alkaloid‐containing plants are widely distributed in the world and are probably
the most common poisonous plants affecting livestock, wildlife, and humans. Because of …
the most common poisonous plants affecting livestock, wildlife, and humans. Because of …
Glutathione transferases in the genomics era: new insights and perspectives
C Frova - Biomolecular engineering, 2006 - Elsevier
In the last decade the tumultuous development of “omics” greatly improved our ability to
understand protein structure, function and evolution, and to define their roles and networks …
understand protein structure, function and evolution, and to define their roles and networks …
Glutathione transferases in bacteria
Bacterial glutathione transferases (GSTs) are part of a superfamily of enzymes that play a
key role in cellular detoxification. GSTs are widely distributed in prokaryotes and are …
key role in cellular detoxification. GSTs are widely distributed in prokaryotes and are …
Exosomes from human macrophages and dendritic cells contain enzymes for leukotriene biosynthesis and promote granulocyte migration
J Esser, U Gehrmann, FL D'Alexandri… - Journal of Allergy and …, 2010 - Elsevier
BACKGROUND: Leukotrienes (LTs) are potent proinflammatory lipid mediators with key
roles in the pathogenesis of asthma and inflammation. Recently, nanovesicles (exosomes) …
roles in the pathogenesis of asthma and inflammation. Recently, nanovesicles (exosomes) …
Oxidative stress, human genetic variation, and disease
L Forsberg, U de Faire, R Morgenstern - Archives of biochemistry and …, 2001 - Elsevier
Oxidative stress has been implicated in numerous pathophysiological conditions and also
aging. The tools for studying oxidative stress are now expanding as a result of the human …
aging. The tools for studying oxidative stress are now expanding as a result of the human …
Biosynthesis and metabolism of leukotrienes
RC Murphy, MA Gijón - Biochemical Journal, 2007 - portlandpress.com
Leukotrienes are metabolites of arachidonic acid derived from the action of 5-LO (5-
lipoxygenase). The immediate product of 5-LO is LTA4 (leukotriene A4), which is …
lipoxygenase). The immediate product of 5-LO is LTA4 (leukotriene A4), which is …
Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents
LG Higgins, JD Hayes - Drug metabolism reviews, 2011 - Taylor & Francis
Glutathione transferase (GST) isoezymes are encoded by three separate families of genes
(designated cytosolic, microsomal and mitochondrial transferases), with distinct evolutionary …
(designated cytosolic, microsomal and mitochondrial transferases), with distinct evolutionary …
Therapeutic options for 5-lipoxygenase inhibitors
O Werz, D Steinhilber - Pharmacology & therapeutics, 2006 - Elsevier
5-Lipoxygenase (5-LO) catalyzes the conversion of arachidonic acid (AA) into leukotriene
(LT) A4 and 5-hydroperoxyeicosatetraenoic acid. LTA4 can then be converted into LTB4 by …
(LT) A4 and 5-hydroperoxyeicosatetraenoic acid. LTA4 can then be converted into LTB4 by …
The plant glutathione transferase gene family: genomic structure, functions, expression and evolution
C Frova - Physiologia plantarum, 2003 - Wiley Online Library
Glutathione transferases (GSTs) are ubiquitous, multifunctional proteins encoded by large
gene families. In different plant species this gene family is comprised of 25–60 members …
gene families. In different plant species this gene family is comprised of 25–60 members …