As the home of cellular genetic information, the nucleus has a critical role in determining cell
fate and function in response to various signals and stimuli. In addition to biochemical …

Biophysical cues, such as mechanical properties, play a critical role in tissue growth and
homeostasis. During organ development and tissue injury repair, compressive and tensional …

The early development of many organisms involves the folding of cell monolayers, but this
behaviour is difficult to reproduce in vitro; therefore, both mechanistic causes and effects of …

YAP/TAZ is a master regulator of mechanotransduction whose functions rely on
translocation from the cytoplasm to the nucleus in response to diverse physical cues …

Exogenous mechanical cues are transmitted from the extracellular matrix to the nuclear
envelope (NE), where mechanical stress on the NE mediates shuttling of transcription …

The biology and physics underlying glioblastoma is not yet completely understood, resulting
in the limited efficacy of current clinical therapy. Recent studies have indicated the …

In eukaryotic cells, the nucleus houses the genomic material of the cell. The physical
properties of the nucleus and its ability to sense external mechanical cues are tightly linked …

The physical confinement of the extracellular matrix (ECM) has been proven to be a
coconspirator in cancer metastasis. However, current experimental models are limited in …

An increasing number of studies have demonstrated the significant roles of the interplay
between microenvironmental mechanics in tissues and biochemical-genetic activities in …

Cardiovascular diseases are the leading cause of global mortality and reduced quality of
life. Human-induced pluripotent stem cells-derived cardiomyocytes (hiPSC-CMs) provide a …