Network biology: understanding the cell's functional organization
AL Barabasi, ZN Oltvai - Nature reviews genetics, 2004 - nature.com
A key aim of postgenomic biomedical research is to systematically catalogue all molecules
and their interactions within a living cell. There is a clear need to understand how these …
and their interactions within a living cell. There is a clear need to understand how these …
A census of human transcription factors: function, expression and evolution
Transcription factors are key cellular components that control gene expression: their
activities determine how cells function and respond to the environment. Currently, there is …
activities determine how cells function and respond to the environment. Currently, there is …
Studying and modelling dynamic biological processes using time-series gene expression data
Biological processes are often dynamic, thus researchers must monitor their activity at
multiple time points. The most abundant source of information regarding such dynamic …
multiple time points. The most abundant source of information regarding such dynamic …
Transcriptional Regulatory Networks in Saccharomyces cerevisiae
We have determined how most of the transcriptional regulators encoded in the eukaryote
Saccharomyces cerevisiae associate with genes across the genome in living cells. Just as …
Saccharomyces cerevisiae associate with genes across the genome in living cells. Just as …
Transcriptional Regulation in Saccharomyces cerevisiae: Transcription Factor Regulation and Function, Mechanisms of Initiation, and Roles of Activators and …
S Hahn, ET Young - Genetics, 2011 - academic.oup.com
Here we review recent advances in understanding the regulation of mRNA synthesis in
Saccharomyces cerevisiae. Many fundamental gene regulatory mechanisms have been …
Saccharomyces cerevisiae. Many fundamental gene regulatory mechanisms have been …
Genomic targets of the human c-Myc protein
PC Fernandez, SR Frank, L Wang… - Genes & …, 2003 - genesdev.cshlp.org
The transcription factor Myc is induced by mitogenic signals and regulates downstream
cellular responses. If overexpressed, Myc promotes malignant transformation. Myc …
cellular responses. If overexpressed, Myc promotes malignant transformation. Myc …
E2F integrates cell cycle progression with DNA repair, replication, and G2/M checkpoints
B Ren, H Cam, Y Takahashi, T Volkert… - Genes & …, 2002 - genesdev.cshlp.org
The E2F transcription factor family is known to play a key role in the timely expression of
genes required for cell cycle progression and proliferation, but only a few E2F target genes …
genes required for cell cycle progression and proliferation, but only a few E2F target genes …
[HTML][HTML] A unified theory of gene expression
G Orphanides, D Reinberg - Cell, 2002 - cell.com
The human genome has been called" the blueprint for life." This master plan is realized
through the process of gene expression. Recent progress has revealed that many of the …
through the process of gene expression. Recent progress has revealed that many of the …
Genomic analysis of regulatory network dynamics reveals large topological changes
Network analysis has been applied widely, providing a unifying language to describe
disparate systems ranging from social interactions to power grids. It has recently been used …
disparate systems ranging from social interactions to power grids. It has recently been used …
Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs
Using high-density oligonucleotide arrays representing essentially all nonrepetitive
sequences on human chromosomes 21 and 22, we map the binding sites in vivo for three …
sequences on human chromosomes 21 and 22, we map the binding sites in vivo for three …