A key aim of postgenomic biomedical research is to systematically catalogue all molecules
and their interactions within a living cell. There is a clear need to understand how these …

Transcription factors are key cellular components that control gene expression: their
activities determine how cells function and respond to the environment. Currently, there is …

Biological processes are often dynamic, thus researchers must monitor their activity at
multiple time points. The most abundant source of information regarding such dynamic …

We have determined how most of the transcriptional regulators encoded in the eukaryote
Saccharomyces cerevisiae associate with genes across the genome in living cells. Just as …

Here we review recent advances in understanding the regulation of mRNA synthesis in
Saccharomyces cerevisiae. Many fundamental gene regulatory mechanisms have been …

The transcription factor Myc is induced by mitogenic signals and regulates downstream
cellular responses. If overexpressed, Myc promotes malignant transformation. Myc …

The E2F transcription factor family is known to play a key role in the timely expression of
genes required for cell cycle progression and proliferation, but only a few E2F target genes …

The human genome has been called" the blueprint for life." This master plan is realized
through the process of gene expression. Recent progress has revealed that many of the …

Network analysis has been applied widely, providing a unifying language to describe
disparate systems ranging from social interactions to power grids. It has recently been used …

Using high-density oligonucleotide arrays representing essentially all nonrepetitive
sequences on human chromosomes 21 and 22, we map the binding sites in vivo for three …