Autophagy in aging and longevity

SQ Wong, AV Kumar, J Mills, LR Lapierre - Human genetics, 2020 - Springer
Our understanding of the process of autophagy and its role in health and diseases has
grown remarkably in the last two decades. Early work established autophagy as a general …

Microplastics and Their Impact on Reproduction—Can we Learn From the C. elegans Model?

E Jewett, G Arnott, L Connolly, N Vasudevan… - Frontiers in …, 2022 - frontiersin.org
Biologically active environmental pollutants have significant impact on ecosystems, wildlife,
and human health. Microplastic (MP) and nanoplastic (NP) particles are pollutants that are …

Antioxidant and anti-aging activities of Laminaria japonica polysaccharide in Caenorhabditis elegans based on metabonomic analysis

N Li, Q Li, X He, X Gao, L Wu, M Xiao, W Cai… - International journal of …, 2022 - Elsevier
In this study, Laminaria japonica polysaccharide (LJP) was measured in vitro against three
antioxidant indicators: DPPH, ABTS, and hydroxyl. In vivo, LJP investigated thermal …

Working with Worms: Caenorhabditis elegans as a Model Organism

PM Meneely, CL Dahlberg… - Current Protocols …, 2019 - Wiley Online Library
Since its introduction as a laboratory organism 50 years ago, the nematode worm
Caenorhabditis elegans has become one of the most widely used and versatile models for …

Bacterial diets differentially alter lifespan and healthspan trajectories in C. elegans

NL Stuhr, SP Curran - Communications Biology, 2020 - nature.com
Diet is one of the more variable aspects in life due to the variety of options that organisms
are exposed to in their natural habitats. In the laboratory, C. elegans are raised on bacterial …

Role of autophagy in lung diseases and ageing

Y Zhang, J Zhang, Z Fu - European Respiratory Review, 2022 - Eur Respiratory Soc
The lungs face ongoing chemical, mechanical, biological, immunological and xenobiotic
stresses over a lifetime. Advancing age progressively impairs lung function. Autophagy is a …

Curcumin supplementation increases longevity and antioxidant capacity in Caenorhabditis elegans

J Xu, P Du, X Liu, X Xu, Y Ge, C Zhang - Frontiers in pharmacology, 2023 - frontiersin.org
Curcumin is well known as a potent antioxidant and free radical scavenger and has great
potential for anti-aging applications. In this study, we investigate the molecular mechanism …

Caenorhabditis elegans as a Model to Study Manganese-Induced Neurotoxicity

AC Martins, P Gubert, J Li, T Ke, MM Nicolai, AV Moura… - Biomolecules, 2022 - mdpi.com
Caenorhabditis elegans (C. elegans) is a nematode present worldwide. The worm shows
homology to mammalian systems and expresses approximately 40% of human disease …

[HTML][HTML] Caenorhabditis elegans as an in vivo model for the identification of natural antioxidants with anti-aging actions

Y Lin, C Lin, Y Cao, Y Chen - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Natural antioxidants have recently emerged as a highly exciting and significant topic in anti-
aging research. Diverse organism models present a viable protocol for future research …

The nematode Caenorhabditis elegans as a model for aging research

HID Mack, T Heimbucher, CT Murphy - Drug Discovery Today: Disease …, 2018 - Elsevier
The nematode Caenorhabditis elegans is a key model system for experimental research on
the genetic regulation of aging, and has paved the way towards many important discoveries …