Networks of molecular regulators are often the primary objects of focus in the study of gene
regulation, with the machinery of protein synthesis tacitly relegated to the background …

The design and optimization of biological systems is an inherently complex undertaking that
requires careful balancing of myriad synergistic and antagonistic variables. However …

The field of optimal experimental design uses mathematical techniques to determine
experiments that are maximally informative from a given experimental setup. Here we apply …

Estimating model parameters is a crucial step in mathematical modelling and typically
involves minimizing the disagreement between model predictions and experimental data …

Highlights•The lack of predictive understanding of circuit behavior limits synthetic biology.•A
major reason for this is the complex interplay between circuit and host state.•Quantitative …

The design and construction of engineered biological systems has made great strides over
the last few decades and a growing part of this is the application of mathematical and …

Synthetic biology—the engineering of cells to rewire the biomolecular networks inside them—
has witnessed phenomenal progress. In a little over a decade it has evolved from …

Synthetic Biology, which is the 'engineering of biology', depends on well-characterized and
standard genetic elements that can be assembled together to construct complex, multi …

Microbial gene expression is a comparatively well understood process, but regulatory
interactions between genes can give rise to complicated behaviours. Regulatory networks …