[HTML][HTML] Leveraging multilayered “omics” data for atopic dermatitis: a road map to precision medicine
D Ghosh, JA Bernstein, GK Khurana Hershey… - Frontiers in …, 2018 - frontiersin.org
Atopic dermatitis (AD) is a complex multifactorial inflammatory skin disease that affects~ 280
million people worldwide. About 85% of AD cases begin in childhood, a significant portion of …
million people worldwide. About 85% of AD cases begin in childhood, a significant portion of …
[HTML][HTML] Periodontal treatment and microbiome-targeted therapy in management of periodontitis-related nonalcoholic fatty liver disease with oral and gut dysbiosis
R Kuraji, T Shiba, TS Dong, Y Numabe… - World journal of …, 2023 - ncbi.nlm.nih.gov
A growing body of evidence from multiple areas proposes that periodontal disease,
accompanied by oral inflammation and pathological changes in the microbiome, induces gut …
accompanied by oral inflammation and pathological changes in the microbiome, induces gut …
[HTML][HTML] Systematic identification of metabolites controlling gene expression in E. coli
Metabolism controls gene expression through allosteric interactions between metabolites
and transcription factors. These interactions are usually measured with in vitro assays, but …
and transcription factors. These interactions are usually measured with in vitro assays, but …
[HTML][HTML] Trans-omic analysis reveals obesity-associated dysregulation of inter-organ metabolic cycles between the liver and skeletal muscle
Systemic metabolic homeostasis is regulated by inter-organ metabolic cycles involving
multiple organs. Obesity impairs inter-organ metabolic cycles, resulting in metabolic …
multiple organs. Obesity impairs inter-organ metabolic cycles, resulting in metabolic …
Crosstalk between transcription and metabolism: how much enzyme is enough for a cell?
Cells employ various mechanisms for dynamic control of enzyme expression. An important
mechanism is mutual feedback—or crosstalk—between transcription and metabolism. As …
mechanism is mutual feedback—or crosstalk—between transcription and metabolism. As …
[HTML][HTML] Trans-omic analysis reveals selective responses to induced and basal insulin across signaling, transcriptional, and metabolic networks
The concentrations of insulin selectively regulate multiple cellular functions. To understand
how insulin concentrations are interpreted by cells, we constructed a trans-omic network of …
how insulin concentrations are interpreted by cells, we constructed a trans-omic network of …
[HTML][HTML] Bone Trans-omics: Integrating Omics to Unveil Mechanistic Molecular Networks Regulating Bone Biology and Disease
Abstract Purpose of Review Recent advancements in “omics” technologies and
bioinformatics have afforded researchers new tools to study bone biology in an unbiased …
bioinformatics have afforded researchers new tools to study bone biology in an unbiased …
Trans‐omic profiling between clinical phenoms and lipidomes among patients with different subtypes of lung cancer
Z Zhu, L Zhang, J Lv, X Liu… - Clinical and Translational …, 2020 - Wiley Online Library
Lung cancer has high mortality, often accompanied with systemic metabolic disorders. The
present study aimed at defining values of trans‐nodules cross‐clinical phenomic and …
present study aimed at defining values of trans‐nodules cross‐clinical phenomic and …
Transomics analysis reveals allosteric and gene regulation axes for altered hepatic glucose-responsive metabolism in obesity
Impaired glucose tolerance associated with obesity causes postprandial hyperglycemia and
can lead to type 2 diabetes. To study the differences in liver metabolism in healthy and …
can lead to type 2 diabetes. To study the differences in liver metabolism in healthy and …
Learning from quantitative data to understand central carbon metabolism
Quantitative analysis of metabolism has been used to identify driver reactions occurring
during cancer development and bottleneck reactions in the metabolic engineering of …
during cancer development and bottleneck reactions in the metabolic engineering of …